Abstract
This study aims to investigate the association of cytokine gene polymorphisms with the risk of Behcet's disease (BD) via comprehensive meta-analysis. The Embase and PubMed databases covering the period from the earliest possible year to May 2015 were searched. A total of 13 eligible articles including 2,065 BD patients and 1,559 controls were recruited. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used to assess the strength of the associations. Potential publication bias was evaluated using Egger's linear regression test. Meta-analysis indicated associations between IL‑6 rs1800795, IL‑12B rs3212227, and IL‑18 rs1946518 in all study subjects: IL‑18 rs1946518 in the dominant model (IL‑18 rs1946518: OR = 0.48, 95 % CI: 0.34-0.70, P = 0.000) and the homozygote model (IL‑18 rs1946518: OR = 0.40, 95 % CI: 0.25-0.65, P = 0.000); and IL‑6 rs1800795 and IL‑12B rs3212227 in the dominant model (IL‑6 rs1800795: OR = 0.53, 95 % CI: 0.39-0.72, P = 0.000; IL‑12B rs3212227: OR = 1.26, 95 % CI: 1.06-1.48, P = 0.007; IL‑18 rs1946518: OR = 0.46, 95 % CI: 0.33-0.65, P = 0.000). No significant evidence for associations of IL‑18 rs187238 polymorphisms with BD susceptibility was detected. In summary, this meta-analysis finds that IL‑6 ...Continue Reading
References
Oct 21, 1999·The New England Journal of Medicine·T SakaneG Inaba
Jan 9, 2003·The Journal of Laboratory and Clinical Medicine·Ilan BankAvi Livneh
Mar 23, 2004·Journal of Dermatological Science·Hirokatsu YanagihoriNobuhisa Mizuki
Jul 13, 2004·Arthritis and Rheumatism·M Ben AhmedH Louzir
Jan 14, 2005·Annals of the Rheumatic Diseases·H K ChangH S Lee
Mar 9, 2006·Journal français d'ophtalmologie·H GuenaneC Touil-Boukoffa
Aug 29, 2006·American Journal of Ophthalmology·Jae Kyoun AhnYeoung Geol Park
Oct 24, 2006·Human Immunology·Yun Jong LeeYeong Wook Song
Jan 11, 2007·Clinical Rheumatology·Gamze AlayliTayyar Cantürk
Mar 9, 2007·Scandinavian Journal of Rheumatology·A M DalghousF Fortune
Jun 27, 2008·Investigative Ophthalmology & Visual Science·Wei ChiAize Kijlstra
Nov 10, 2010·European Cytokine Network·Aliakbar AmirzargarFereydoun Davatchi
Apr 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Kamel HamzaouiAgnes Hamzaoui
May 3, 2011·The Journal of Rheumatology·Jasmine HtoonAmr H Sawalha
Dec 14, 2011·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Qingping YaoXiaofeng Wang
Mar 2, 2012·Arthritis and Rheumatism·Joana M XavierSofia A Oliveira
Apr 10, 2012·Life Sciences·Eun Soo KimJae Hee Cheon
Nov 26, 2013·International Journal of Rheumatic Diseases·Yan LiangDong-Qing Ye
Apr 8, 2014·Immunobiology·Roba M TalaatAhmed A Raouf
May 27, 2014·PloS One·Xinyu LiPeizeng Yang
Jun 18, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Hala H A HazzaaEnas A S Attia
Jul 26, 2014·Journal of Immunology Research·Un Chul ParkHyeong Gon Yu
Citations
Apr 17, 2019·Current Rheumatology Reviews·Israel Gañán Nieto, José Luis Castañer Alabau
Dec 15, 2018·Journal of Cellular and Molecular Medicine·Qiang FuWei Lin
Jan 1, 2020·Journal of Inflammation·Elham ShahriyariMaryam Ghaffari Laleh