Association of cytotoxic T lymphocyte antigen-4 gene polymorphisms and HLA class II alleles with the development of type 1 diabetes in Korean children and adolescents.

Journal of Korean Medical Science
Min Ho JungByung Churl Lee

Abstract

We studied the association of cytotoxic T lymphocyte antigen-4 gene (CTLA4) polymorphisms with the development of type 1 diabetes (T1D) in Korean children and adolescents. A total of 176 Korean subjects (92 females and 84 males) with childhood-onset T1D were studied. The A/G polymorphism at position 49 in CTLA4 exon 1 and the C/T polymorphism at position -318 in the CTLA4 promoter were analyzed by PCR-RFLP methods. The genotype and allele frequencies of the CTLA4 polymorphisms in the T1D patients were not different from those in the controls. These polymorphisms were not associated with the clinical characteristics or the development of autoimmune thyroid disease in the T1D patients. The frequency of the A allele was significantly higher in the patients that did not have two out of the three susceptible HLA-DRB1 alleles, which were DRB1*0301, *0405 and *09012, compared to the controls (P<0.05). These results suggest that CTLA4 polymorphisms do not directly confer any susceptibility to T1D. However, a CTLA4-mediated susceptibility effect on the development of T1D might be significant in children and adolescents that do not have susceptible HLA class II alleles.

References

May 22, 1986·The New England Journal of Medicine·G S Eisenbarth
Aug 1, 1994·Immunity·T L WalunasJ A Bluestone
Jun 1, 1996·The Journal of Experimental Medicine·T L WalunasJ A Bluestone
Aug 23, 1996·Biochemical and Biophysical Research Communications·K DeichmannJ Kuehr
Feb 1, 1994·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·M BannaiT Juji
Feb 12, 1998·Thyroid : Official Journal of the American Thyroid Association·T YanagawaT Saruta
Apr 15, 1999·Tissue Antigens·M F Gonzalez-EscribanoA Nuñez-Roldan
Oct 20, 1999·Human Immunology·M H ParkS J Kang
Jul 25, 2000·Thyroid : Official Journal of the American Thyroid Association·Y J ParkB Y Cho
Jun 27, 2001·Genes and Immunity·A LigersJ Hillert
Jul 28, 2005·Diabetes·Andrea K SteckMarian J Rewers

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Citations

Apr 27, 2011·International Journal of Colorectal Disease·Veronika CsöngeiBéla Melegh
Sep 27, 2012·Genetic Testing and Molecular Biomarkers·Xiaoyu SiWenru Tang
Apr 26, 2011·Human Immunology·Zulkarnain Md IdrisRahmah Noordin
Oct 15, 2019·Annals of Pediatric Endocrinology & Metabolism·Hae Sang Lee, Jin Soon Hwang
Jul 1, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity

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