Association of Delirium Response and Safety of Pharmacological Interventions for the Management and Prevention of Delirium: A Network Meta-analysis

JAMA Psychiatry
Yi-Cheng WuKuan-Pin Su

Abstract

Although several pharmacological interventions for delirium have been investigated, their overall benefit and safety remain unclear. To evaluate evidence regarding pharmacological interventions for delirium treatment and prevention. PubMed, Embase, ProQuest, ScienceDirect, Cochrane Central, Web of Science, ClinicalKey, and ClinicalTrials.gov from inception to May 17, 2018. Randomized clinical trials (RCTs) examining pharmacological interventions for delirium treatment and prevention. To extract data according to a predetermined list of interests, the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guidelines were applied, and all meta-analytic procedures were conducted using a random-effects model. The primary outcomes were treatment response in patients with delirium and the incidence of delirium in patients at risk of delirium. A total of 58 RCTs were included, in which 20 RCTs with 1435 participants (mean age, 63.5 years; 65.1% male) compared the outcomes of treatment and 38 RCTs with 8168 participants (mean age, 70.2 years; 53.4% male) examined the prevention of delirium. A network meta-analysis demonstrated that haloperidol plus lorazepam provided the best response rate for delirium treatment (o...Continue Reading

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Jul 4, 2019·JAMA Psychiatry·Ping-Tao Tseng, Kuan-Pin Su
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