Association of Dengue Virus and Leptospira Co-Infections with Malaria Severity.

Emerging Infectious Diseases
Rajendra MandagePragyan Acharya

Abstract

Plasmodium infections are co-endemic with infections caused by other agents of acute febrile illnesses, such as dengue virus (DENV), chikungunya virus, Leptospira spp., and Orientia tsutsugamushi. However, co-infections may influence disease severity, treatment outcomes, and development of drug resistance. When we analyzed cases of acute febrile illness at the All India Institute of Medical Sciences, New Delhi, India, from July 2017 through September 2018, we found that most patients with malaria harbored co-infections (Plasmodium mixed species and other pathogens). DENV was the most common malaria co-infection (44% of total infections). DENV serotype 4 was associated with mild malaria, and Leptospira was associated with severe malaria. We also found the presence of P. knowlesi in our study population. Therefore, in areas with a large number of severe malaria cases, diagnostic screening for all 4 DENV serotypes, Leptospira, and all Plasmodium species should be performed.

References

Jun 15, 2007·Transactions of the Royal Society of Tropical Medicine and Hygiene·Rajeev M KaushikKunwar J B S Gaur
Sep 2, 2008·Emerging Infectious Diseases·Anu KanteleT Sakari Jokiranta
Apr 1, 2009·Emerging Infectious Diseases·Bernard CarmeJacques Morvan
Oct 1, 2009·Emerging Infectious Diseases·Jaap J van HellemondPerry J J van Genderen
Mar 31, 2010·Emerging Infectious Diseases·Melanie FigtreeBernard J Hudson
Apr 23, 2013·Case Reports in Medicine·Mohsin Bin MushtaqAaliya Rashid
May 7, 2013·Asian Pacific Journal of Tropical Biomedicine·Anwar Alam, Md Dm
Aug 13, 2013·PLoS Neglected Tropical Diseases·Maria Rosario CapedingTram Anh Wartel
Aug 15, 2013·Malaria Journal·Jonas EhrhardtMatthias Frank
Nov 6, 2013·Pathogens and Global Health·John LindoEva Lewis-Fuller
Nov 21, 2014·PLoS Neglected Tropical Diseases·Beatrice ChipwazaPaul S Gwakisa
Feb 8, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S AhmadV Gupta
Oct 7, 2016·The American Journal of Tropical Medicine and Hygiene·Anupkumar R AnvikarNeena Valecha
Oct 6, 2017·BMC Infectious Diseases·Kristine MørchDilip Mathai
Feb 21, 2018·Emerging Infectious Diseases·Araia BerhaneJane Cunningham
Oct 9, 2018·The Journal of Infectious Diseases·Nicholas M Anstey, Matthew J Grigg

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

Stata
R
Excel

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.