Association of depression with coronary artery disease and QTc interval prolongation in women with chest pain: data from the KoRean wOmen'S chest pain rEgistry (KoROSE) study

Physiology & Behavior
Kyoung Im ChoKyoung-Soon Hong

Abstract

The presence of depression is reportedly related with cardiovascular diseases, including coronary artery disease (CAD), but little is known concerning the association between depressive symptoms reflecting the cultural constructions of female patients with chest pain as well as coronary artery stenosis, coronary vasospasm, and the corrected QT (QTc) interval. In a multicenter prospective cross-sectional survey of 163 Korean women with chest pain, the presence of depression was evaluated using the Beck Depression Inventory (BDI) and Lee and Rhee Depression (LRD) scales. The differences in the QTc interval and the presence of CAD (defined as ≥ 50% coronary artery stenosis on coronary angiography) and coronary vasospasm were compared between depressed and non-depressed women. Significant CAD was present in 83 of 163 female patients (mean age, 61 years), and coronary vasospasm was present in 11 of 80 patients. The mean BDI and LRD scores were significantly higher in patients with significant CAD (BDI: 13.4 ± 9.6 vs. 6.9 ± 5.6, p < 0.001; LRD: 46.9 ± 21.4 vs. 39.8 ± 15.2, p = 0.027) and coronary vasospasm (BDI: 12.3 ± 6.4 vs. 4.6 ± 2.8; and LRD: 49.8 ± 12.3 vs. 30.5 ± 13.9; both p < 0.05). On multivariate analysis, BDI scores were i...Continue Reading

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