Association of depressive symptoms with circadian blood pressure alterations in Parkinson's disease

Journal of Neurology
Davide L VetranoGiuseppe Zuccalà

Abstract

To assess whether among patients with Parkinson's disease (PD) depression, a common non-motor symptom associated with reduced survival, is associated with cardiovascular dysautonomia. We enrolled 125 subjects with PD consecutively admitted to a geriatric day hospital. All participants underwent comprehensive evaluation, fasting blood sampling, and 24-h ambulatory blood pressure monitoring. The percent reduction in nocturnal blood pressure (dipping) was calculated. Depressive symptoms were assessed through the 15-item Geriatric Depression Scale (GDS); a score ≥5 identified moderate to severe symptoms. Among participants (mean age 72.7 ± 7.8 years, 32 % women) 61 subjects (49 %) presented with a GDS score ≥ 5. When compared with other participants, subjects with a GDS score ≥ 5 had reduced adjusted levels of percent systolic (-2.6 ± 2.7 vs. 4.7 ± 2.5; p = 0.003), diastolic (0.6 ± 2.8 vs. 7.4 ± 2.6; p = 0.007), and mean blood pressure dipping (-0.7 ± 2.6 vs. 6.8 ± 2.5; p = 0.002). In separate logistic regression models, depressive symptoms were associated with reduced systolic (OR 0.94; 95 % CI 0.89; 0.98), diastolic (OR 0.94; 95 % CI 0.90; 0.99), and mean blood pressure dipping (OR 0.93; 95 % CI 0.89; 0.98), after adjusting for p...Continue Reading

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Citations

Nov 20, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Karim Fifel
Nov 3, 2016·The Journal of Clinical Hypertension·Davide L VetranoGiuseppe Zuccalà
Mar 17, 2019·Aging Clinical and Experimental Research·Maria S PisciottaDavide L Vetrano
Oct 31, 2020·Parkinson's Disease·Daniel Martinez-RamirezMirna Gonzalez-Gonzalez
Feb 5, 2021·Frontiers in Neuroscience·Karim Fifel, Aleksandar Videnovic
Mar 7, 2021·Journal of Personalized Medicine·Delia TulbăBogdan Ovidiu Popescu
Aug 8, 2021·Parkinsonism & Related Disorders·Daniel J van WamelenUNKNOWN International Parkinson and Movement Disorder Society Non Motor Parkinson's Disease Study Group

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