Association of diabetic neuropathy with Na/K ATPase gene polymorphism

Diabetologia
P VagueD Raccah

Abstract

Diabetes mellitus induces a decrease in Na/K ATPase activity in man and animals, and this decrease plays a role in the development of diabetic neuropathy. Na/K ATPase is encoded by various genes, of which the ATP1 A1 gene is expressed predominantly in peripheral nerves and in erythrocytes. To investigate whether a polymorphism in the Na/K ATPase genes could explain the predisposition of some patients with insulin-dependent diabetes mellitus (IDDM) to develop polyneuropathy, a restriction fragment length polymorphism (RFLP) of the ATP1 A1 gene was studied together with erythrocyte Na/K ATPase activity in 81 Caucasian patients with more than 10 years' duration of IDDM. Associations with diabetic neuropathy, retinopathy and nephropathy were sought. Digestion of the first intron of the ATP1 A1 gene by the Bgl II restriction enzyme revealed a dimorphic allelism. Frequency of the restricted allele was 0.18 in this selected series (however, it was 0.10 in representative samples of IDDM patients and of normal subjects in our area). Mean erythrocyte Na/K ATPase activity was lower in diabetic patients than in 42 control subjects (292 +/- 10, vs 402 +/- 13 nmol Pi.mg protein-1.h-1, p < 0.0001) and was not related to HbA1c value or to diab...Continue Reading

Citations

Aug 5, 2004·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Michaella GoldsteinRafi Korenstein
Jun 6, 2007·Diabetes Research and Clinical Practice·Guanjie ChenCharles Rotimi
Aug 2, 2008·Experimental Diabetes Research·T ForstA Pfützner
Nov 25, 2005·Cephalalgia : an International Journal of Headache·O AppenzellerY Wang
May 14, 2017·Journal of Cellular Physiology·Harish C ChandramoorthyMohamed A Haidara
Dec 1, 2005·Molecular and Cellular Biochemistry·Rangasamy SampathkumarViswanathan Mohan
Sep 27, 2019·Annals of Clinical and Translational Neurology·Yating ZhaoXu Liu
Sep 10, 2003·Journal of Applied Physiology·Satu PajalaTaina Rantanen
Feb 11, 2000·Medizinische Klinik·T Klemm, R Paschke
Mar 31, 2010·Molecular Biology Reports·Javad Tavakkoly-BazzazIan V Hutchinson
Sep 17, 2019·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Mohammed A AbosheashaTarek M Mohamed
Aug 28, 2021·Animals : an Open Access Journal From MDPI·Muhammed Elayadeth-MeethalMichael R F Lee

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