Association of Dietary Nitrate Intake With Primary Open-Angle Glaucoma: A Prospective Analysis From the Nurses' Health Study and Health Professionals Follow-up Study

JAMA Ophthalmology
Jae H KangLouis R Pasquale

Abstract

Nitric oxide signaling alterations in outflow facility and retinal blood flow autoregulation are implicated in primary open-angle glaucoma (POAG). Nitric oxide donation has emerged as a POAG therapeutic target. An exogenous source of nitric oxide is dietary nitrates. To evaluate the association between dietary nitrate intake, derived mainly from green leafy vegetables, and POAG. We followed up participants biennially in the prospective cohorts of the Nurses' Health Study (63 893 women; 1984-2012) and the Health Professionals Follow-up Study (41 094 men; 1986-2012) at each 2-year risk period. Eligible participants were 40 years or older, were free of POAG, and reported eye examinations. The primary exposure was dietary nitrate intake. Information on diet and potential confounders was updated with validated questionnaires. The main outcome was the incidence of POAG and POAG subtypes; 1483 cases were confirmed with medical records and classified into subtypes defined by intraocular pressure (IOP) (≥22 or <22 mm Hg) or by visual field (VF) loss pattern at diagnosis (peripheral loss only or early paracentral loss). Cohort-specific and pooled multivariable rate ratios (MVRRs) and 95% CIs were estimated. During 1 678 713 person-years ...Continue Reading

Citations

Feb 6, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Michael W GaynonSam E Mansour
Jan 16, 2017·American Journal of Ophthalmology·Mengyu WangTobias Elze
Mar 17, 2018·Nutrients·Wishal D RamdasCarroll A B Webers
Aug 8, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Megan E Cavet, Heleen H DeCory
Feb 10, 2018·Ophthalmology and Therapy·Adi M Al Owaifeer, Abdulaziz A Al Taisan
Feb 21, 2018·Acta Ophthalmologica·Wishal D Ramdas
Nov 27, 2018·Translational Neuroscience·Qing YangLin Luo
Dec 19, 2018·Current Opinion in Ophthalmology·Claudio I PerezShan Lin
Jan 24, 2019·The British Journal of Nutrition·Jacklyn K JacksonMark A McEvoy
May 10, 2019·European Journal of Sport Science·Jesús VeraAmador García-Ramos
Oct 4, 2020·European Journal of Ophthalmology·Sayena JabbehdariThasarat Sutabutr Vajaranant
Oct 16, 2018·The American Journal of Clinical Nutrition·Abrar M BabateenMario Siervo
Oct 16, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Idan HechtZvia Burgansky-Eliash
Jan 16, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Stephanie WeyL Jay Katz
Aug 8, 2020·Scientific Reports·Ji Won ParkAlan N Schechter
Jul 28, 2016·Clinical & Experimental Ophthalmology·Andrea L Vincent, Alex P Hunyor
Sep 24, 2020·Nutrients·Sarah G FranciscoSheldon Rowan
Nov 28, 2020·Translational Vision Science & Technology·Bettina TengMengyu Wang
Dec 1, 2020·Progress in Retinal and Eye Research·Ester Reina-TorresW Daniel Stamer
May 1, 2021·International Journal of Molecular Sciences·Anna-Sophie Mursch-EdlmayrClemens Strohmaier
Jun 9, 2021·BMC Sports Science, Medicine and Rehabilitation·Oliver M ShannonTom Clifford
Jun 12, 2021·Clinical Ophthalmology·Noriko HimoriToru Nakazawa
Jul 3, 2021·Nutrients·Drake W LemPinakin Gunvant Davey

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.