Association of Dietary Patterns and Type-2 Diabetes Mellitus in Metabolically Homogeneous Subgroups in the KORA FF4 Study.

Nutrients
Nina WawroJakob Linseisen

Abstract

There is evidence that a change in lifestyle, especially physical activity and diet, can reduce the risk of developing type-2 diabetes mellitus (T2DM). However, the response to dietary changes varies among individuals due to differences in metabolic characteristics. Therefore, we investigated the association between dietary patterns and T2DM while taking into account these differences. For 1287 participants of the population-based KORA FF4 study (Cooperative Health Research in the Region of Augsburg), we identified three metabolically-homogenous subgroups (metabotypes) using 16 clinical markers. Based on usual dietary intake data, two diet quality scores, the Mediterranean Diet Score (MDS) and the Alternate Healthy Eating Index (AHEI), were calculated. We explored the associations between T2DM and diet quality scores. Multi-variable adjusted models, including metabotype subgroup, were fitted. In addition, analyses stratified by metabotype were carried out. We found significant interaction effects between metabotype and both diet quality scores (p < 0.05). In the analysis stratified by metabotype, significant negative associations between T2DM and both diet quality scores were detected only in the metabolically-unfavorable homog...Continue Reading

References

Dec 2, 1995·BMJ : British Medical Journal·A TrichopoulouD Trichopoulos
Jan 16, 2002·Current Opinion in Lipidology·Frank B Hu
Mar 5, 2002·Diabetes Care·Joyce Green PastorsKarmeen Kulkarni
Nov 27, 2002·The American Journal of Clinical Nutrition·Marjorie L McCulloughWalter C Willett
Jun 27, 2003·The New England Journal of Medicine·Antonia TrichopoulouDimitrios Trichopoulos
Jul 21, 2005·Das Gesundheitswesen·R HolleUNKNOWN MONICA/KORA Study Group
Oct 4, 2006·Molecular Systems Biology·Jeremy K Nicholson
Sep 9, 2008·Cell·Elaine HolmesJeremy K Nicholson
Jan 29, 2010·Diabetes Care·UNKNOWN American Diabetes Association
Apr 6, 2011·Diabetes Care·Lawrence de KoningFrank B Hu
May 4, 2011·World Journal of Diabetes·Christina-Maria Kastorini, Demosthenes B Panagiotakos
Apr 20, 2012·The Journal of Nutrition·Stephanie E ChiuveWalter C Willett
Jun 12, 2012·Lancet·Adam G TabákMika Kivimäki
Nov 16, 2012·Nature·Jeremy K NicholsonJohn C Lindon
Dec 4, 2012·The Proceedings of the Nutrition Society·Baukje de Roos
Jul 25, 2014·Medicine and Science in Sports and Exercise·Russell R PateMarsha Dowda
Aug 26, 2014·Public Health Nutrition·Lukas SchwingshacklGeorg Hoffmann
Aug 12, 2015·The Proceedings of the Nutrition Society·Clare B O'DonovanLorraine Brennan
Mar 5, 2016·American Journal of Epidemiology·Elizabeth M CespedesMarian L Neuhouser
Jun 16, 2016·Experimental Biology and Medicine·Ben BrannickSamuel Dagogo-Jack
Jul 9, 2016·Nature Reviews. Endocrinology·Paul ZimmetPeter H Bennett
Sep 14, 2016·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·S OnvaniL Azadbakht
Sep 20, 2016·Metabolomics : Official Journal of the Metabolomic Society·Richard D BegerUNKNOWN for “Precision Medicine and Pharmacometabolomics Task Group”-Metabolomics Society Initiative
Nov 12, 2016·Current Opinion in Biotechnology·Lorraine Brennan
Apr 11, 2017·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Nerea Becerra-TomásUNKNOWN PREDIMED Study Investigators
Jul 20, 2017·The British Journal of Nutrition·Anna RiedlJakob Linseisen
Oct 24, 2017·The British Journal of Nutrition·Clare B O'DonovanLorraine Brennan
Dec 21, 2017·Frontiers in Nutrition·Micah G DonovanDonato F Romagnolo
Mar 3, 2018·Diabetes Research and Clinical Practice·N H ChoB Malanda
Jun 28, 2018·BMC Medicine·Cecilia GalbeteMatthias B Schulze

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Methods Mentioned

BETA
MDS

Software Mentioned

Soft
R
MDS
R Foundation for Statistical Computing
EPIC
MICE

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