Association of differential miRNA expression with hepatic vs. peritoneal metastatic spread in colorectal cancer

BMC Cancer
Sabine HeubleinMartin Angele

Abstract

Though peritoneal carcinomatosis reflects a late stage of colorectal cancer (CRC), only few patients present with synchronous or metachronous liver metastases alongside their peritoneal carcinomatosis. It is hypothesized that this phenomenon may be causally linked to molecular characteristics of the primary CRC. This study used miRNA profiling of primary CRC tissue either metastasized to the liver, to the peritoneum or not metastasized at all thus to identify miRNAs potentially associated with defining the site of metastatic spread in CRC. Tissue of the primary tumor stemming from CRC patients diagnosed for either liver metastasis (LM; n = 10) or peritoneal carcinomatosis (PER; n = 10) was analyzed in this study. Advanced CRC cases without metastasis (M0; n = 3) were also included thus to select on those miRNAs most potentially associated with determining metastatic spread in general. miRNA profiling of 754 different miRNAs was performed in each group. MiRNAs being either differentially expressed comparing PER and LM or even triple differentially expressed (PER vs. LM vs. M0) were identified. Differentially expressed miRNAs were further validated by in silico and functional analysis. Comparative analysis identified 41 miRNAs to...Continue Reading

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Citations

Jun 5, 2020·Artificial Cells, Nanomedicine, and Biotechnology·Dan JiQiong Fang

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Methods Mentioned

BETA
antisense oligo-nucleotides
surgical resection
PCR
transfection
electrophoresis

Software Mentioned

miRCancer
SPSS
QuantityOne

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