Association of Digoxin With Interstage Mortality: Results From the Pediatric Heart Network Single Ventricle Reconstruction Trial Public Use Dataset

Journal of the American Heart Association
Matthew E OsterWilliam T Mahle

Abstract

Mortality for infants with single ventricle congenital heart disease remains as high as 8% to 12% during the interstage period, the time between discharge after the Norwood procedure and before the stage II palliation. The objective of our study was to determine the association between digoxin use and interstage mortality in these infants. We conducted a retrospective cohort study using the Pediatric Heart Network Single Ventricle Reconstruction Trial public use dataset, which includes data on infants with single right ventricle congenital heart disease randomized to receive either a Blalock-Taussig shunt or right ventricle-to-pulmonary artery shunt during the Norwood procedure at 15 institutions in North America from 2005 to 2008. Parametric survival models were used to compare the risk of interstage mortality between those discharged to home on digoxin versus those discharged to home not on digoxin, adjusting for center volume, ascending aorta diameter, shunt type, and socioeconomic status. Of the 330 infants eligible for this study, 102 (31%) were discharged home on digoxin. Interstage mortality for those not on digoxin was 12.3%, compared to 2.9% among those on digoxin, with an adjusted hazard ratio of 3.5 (95% CI, 1.1-11.7...Continue Reading

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Citations

Jul 25, 2018·Cardiology in the Young·Aaron EckhauserL LuAnn Minich
Sep 22, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Matthew D Files, Bhawna Arya
Jun 9, 2020·Biometrics·Xiaofei ChenHaekyung Jeon-Slaughter
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Jul 10, 2021·The American Journal of Cardiology·Rachel E KlausnerJustin Godown
May 19, 2019·The Journal of Thoracic and Cardiovascular Surgery·Tara KaramlouKevin D Hill

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