Association of Disease Progression With Health-Related Quality of Life Among Adults With Breast, Lung, Pancreatic, and Colorectal Cancer

JAMA Network Open
Norbert MarschnerMartina Jänicke

Abstract

Mortality, morbidity, and health-related quality of life (HRQoL) are patient-relevant end points generally considered in the early benefit assessments of new cancer treatments. Progression-related end points, such as time to progression or progression-free survival, are not included, although patients and physicians testify to the detrimental association of disease progression with HRQoL. To examine the association of disease progression and HRQoL in 4 prevalent solid-cancer entities in routine clinical practice. This cohort study evaluated data from 4 prospective, nonintervention, multicenter registries collected between 2011 and 2018 in 203 centers in Germany. Patients' HRQoL was assessed regularly for up to 5 years. The change in HRQoL scores after disease progression was examined with linear mixed models, adjusting for demographic and clinical covariates. Patients with metastatic breast, pancreatic, lung, and colorectal cancer were recruited at the start of systemic first-line treatment. Data analysis was performed from February 2019 to April 2019. All patients received systemic, palliative first-line treatment according to their physician's choice. The primary outcome was deterioration of HRQoL associated with disease prog...Continue Reading

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Oct 20, 2020·Journal of Medical Economics·Shinya OhnoKatsura Tsukamoto
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