Abstract
It has previously been demonstrated that immunosuppressed patients with cutaneous squamous cell cancer of the head and neck (cSCC-HN) treated with surgery and postoperative radiotherapy have significantly inferior disease-related outcomes compared with immunocompetent patients, but data on outcomes after disease recurrence are limited. To report survival outcomes in patients with cSCC-HN after disease recurrence after surgery and postoperative radiotherapy and to investigate the association of immune status with disease-related outcomes. A multi-institutional study of 205 patients treated at the Cleveland Clinic, Washington University in St Louis, and the University of California, San Francisco, in which patients who underwent surgical resection and postoperative radiotherapy for primary or recurrent stage I to IV (nonmetastatic) cSCC-HN between January 1, 1995, and December 31, 2014, were identified. Patients with any disease recurrence, defined as local, regional, and/or distant failure, were included. Patients were categorized as immunosuppressed if they received a diagnosis of chronic hematologic malignant neoplasm or HIV or AIDS, or were treated with immunosuppressive therapy for organ transplantation 6 months or more befo...Continue Reading
References
Aug 5, 1998·The American Journal of Physiology·M K Slodzinski, M P Blaustein
Jan 12, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dong M ShinScott M Lippman
Jul 21, 2004·Archives of Dermatology·Kevan G Lewis, Martin A Weinstock
Jul 12, 2008·The Lancet Oncology·Kay D BrantschHelmut Breuninger
Sep 3, 2010·Transplantation·David G LottRobert R Lorenz
Aug 4, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eve MaubecMarie-Françoise Avril
Apr 22, 2015·The New England Journal of Medicine·Caroline RobertUNKNOWN KEYNOTE-006 investigators
Jun 2, 2015·Journal of the American Academy of Dermatology·Bindu V ManyamShlomo A Koyfman
Nov 13, 2015·The New England Journal of Medicine·Timothy A ChanAlexandra Snyder
Apr 20, 2016·The New England Journal of Medicine·Paul T NghiemMartin A Cheever
Nov 3, 2016·The New England Journal of Medicine·Vassiliki A Boussiotis
Sep 12, 2017·The New England Journal of Medicine·Jedd D WolchokJames Larkin
Sep 12, 2017·The New England Journal of Medicine·Jeffrey WeberUNKNOWN CheckMate 238 Collaborators
Oct 2, 2017·Journal of the American Academy of Dermatology·William N WilliamEdward S Kim
Mar 15, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sandro Virgilio PorcedduDanny Rischin
Jun 5, 2018·The New England Journal of Medicine·Michael R MigdenMatthew G Fury
Citations
Jul 7, 2020·ANZ Journal of Surgery·Jason ToppiMatthew J R Magarey
Feb 24, 2021·Plastic and Reconstructive Surgery·Thomas J KnackstedtDavid R Crowe
Feb 20, 2021·ClinicoEconomics and Outcomes Research : CEOR·Gianni GhettiLorenzo Pradelli
Mar 2, 2021·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Gerasimos KonidarisShannon Cope
May 1, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·Jinjue ZhangJunjie Chen
Jun 14, 2021·Radiation Oncology·Erik HaehlNils H Nicolay
Aug 6, 2021·Journal of Managed Care & Specialty Pharmacy·Eleanor PaulAndreas Kuznik
Sep 19, 2021·International Wound Journal·Ahmed K MousaSherif E Sayed