Association of disrupted circadian rhythmicity with mood disorders, subjective wellbeing, and cognitive function: a cross-sectional study of 91 105 participants from the UK Biobank.

The Lancet. Psychiatry
Laura M LyallDaniel J Smith

Abstract

Disruption of sleep and circadian rhythmicity is a core feature of mood disorders and might be associated with increased susceptibility to such disorders. Previous studies in this area have used subjective reports of activity and sleep patterns, but the availability of accelerometer-based data from UK Biobank participants permits the derivation and analysis of new, objectively ascertained circadian rhythmicity parameters. We examined associations between objectively assessed circadian rhythmicity and mental health and wellbeing phenotypes, including lifetime history of mood disorder. UK residents aged 37-73 years were recruited into the UK Biobank general population cohort from 2006 to 2010. We used data from a subset of participants whose activity levels were recorded by wearing a wrist-worn accelerometer for 7 days. From these data, we derived a circadian relative amplitude variable, which is a measure of the extent to which circadian rhythmicity of rest-activity cycles is disrupted. In the same sample, we examined cross-sectional associations between low relative amplitude and mood disorder, wellbeing, and cognitive variables using a series of regression models. Our final model adjusted for age and season at the time that ac...Continue Reading

Citations

Nov 8, 2018·The European Journal of Neuroscience·Céline Vetter
Feb 21, 2019·The Journal of Physiology·Shawn D YoungstedtDaniel F Kripke
Mar 31, 2019·The Medical Journal of Australia·Andre Q Andrade, Elizabeth E Roughead
Jul 24, 2020·Journal of Biological Rhythms·Derk-Jan Dijk, Jeanne F Duffy
Aug 23, 2019·Translational Psychiatry·Niall M McGowanKate E A Saunders
Jun 20, 2019·International Journal of Environmental Research and Public Health·Sheng Zhi ZhaoTai Hing Lam
Aug 15, 2020·Frontiers in Psychiatry·Jerome Clifford FooMarcella Rietschel
Apr 6, 2019·Frontiers in Neuroscience·Jeremy F HuckinsAndrew T Campbell
Mar 3, 2020·Frontiers in Neurology·Pei-Lin YangElizabeth C Parsons
Jul 29, 2020·Nutrients·Jolana Wagner-SkacelSusanne Bengesser
Dec 14, 2018·Postgraduate Medical Journal·Rachael M KellyAndrew N Coogan
Jul 1, 2020·Psychological Medicine·Jennifer L BurgessR Hamish McAllister-Williams
May 16, 2019·The Australian and New Zealand Journal of Psychiatry·Greg Murray
May 7, 2019·Chronobiology International·Melissa A B de OliveiraMaria Paz Hidalgo
Sep 5, 2020·Science·Seán T Anderson, Garret A FitzGerald
Oct 2, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Andrew LerouxCiprian Crainiceanu
Jan 6, 2021·International Journal of Psychiatry in Clinical Practice·Andrea AgugliaGiuseppe Maina
Jan 16, 2021·Translational Psychiatry·Chad SmithGiulio Maria Pasinetti
Nov 24, 2020·Chronobiology International·Teresa C D'Oliveira, Antonio Anagnostopoulos
Feb 14, 2021·Journal of Affective Disorders·Bruno EtainJan Scott
Dec 30, 2020·Nutrients·Aneta Otocka-Kmiecik, Aleksandra Król
Mar 11, 2021·Neuroscience and Biobehavioral Reviews·Joanne S CarpenterIan B Hickie
Apr 30, 2021·Journal of Sleep Research·Masoud TahmasianMojtaba Zarei

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