Association of DNA methylation and monoamine oxidase A gene expression in the brains of different dog breeds

Gene
Jungwoo EoHeui-Soo Kim

Abstract

The monoamine oxidase A (MAOA) gene is an important candidate gene for human behavior that encodes an enzyme regulating the metabolism of key neurotransmitters. The regulatory mechanisms of the MAOA gene in dogs are yet to be elucidated. We measured MAOA gene transcription and analyzed the VNTR genotype and methylation status of the gene promoter region in different dog breeds to determine whether MAOA expression is correlated with the MAOA genotype or epigenetic modification in dogs. We found brain-specific expression of the MAOA gene and different transcription levels in different dog breeds including Beagle, Sapsaree, and German shepherd, and also a robust association of the DNA methylation of the gene promoter with mRNA levels. However, the 90 bp tandem repeats that we observed near the transcription start site were not variable, indicating no correlation with canine MAOA activity. These results show that differential DNA methylation in the MAOA promoter region may affect gene expression by modulating promoter activity. Moreover, the distinctive patterns of MAOA expression and DNA methylation may be involved in breed-specific or individual behavioral characteristics, such as aggression, because behavioral phenotypes are rel...Continue Reading

References

Jun 1, 1995·The Quarterly Review of Biology·A Boissy
Nov 3, 1998·Human Genetics·S Z SabolD Hamer
Dec 24, 1998·Nucleic Acids Research·G Benson
Mar 24, 1999·Trends in Genetics : TIG·P A Jones
Aug 12, 1999·American Journal of Human Genetics·J C Shih, R F Thompson
May 29, 2002·Nature Genetics·Fei XueXiangzhong Yang
Dec 24, 2002·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Deborah C LawsonAnita Thapar
Sep 3, 2003·The Journal of Veterinary Medical Science·Chie HashizumeYuji Mori
Oct 11, 2003·Science·Charles W WhitfieldGene E Robinson
Jun 3, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kazuya IwamotoTadafumi Kato
Apr 12, 2006·The Journal of Biological Chemistry·Jonathan M LevensonJ David Sweatt
May 10, 2006·PLoS Genetics·Yong-Qing FengEric E Bouhassira
Aug 8, 2006·Biochemical and Biophysical Research Communications·Niklas Nordquist, Lars Oreland
Sep 21, 2006·Human Molecular Genetics·Hamid Mostafavi AbdolmalekySam Thiagalingam
Jun 15, 2007·Human Molecular Genetics·Elizabeth T Cirulli, David B Goldstein
Mar 6, 2008·American Journal of Human Genetics·Jonathan MillArturas Petronis
May 6, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Robert A PhilibertAnup Madan
May 9, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nelly Alia-KleinJoanna S Fowler
Oct 17, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Farah D LubinJ David Sweatt
Feb 24, 2010·Journal of Family Psychology : JFP : Journal of the Division of Family Psychology of the American Psychological Association (Division 43)·Steven R H BeachRobert A Philibert
Jun 26, 2010·Molecular Reproduction and Development·A R FerreiraM M Franco
Mar 2, 2011·Journal of Neural Transmission·Jean C ShihKevin Chen
Aug 15, 2012·Drug Discoveries & Therapeutics·Jeremy DuncanXiao-Ming Ou
Sep 6, 2012·Epigenetics : Official Journal of the DNA Methylation Society·Elena ShumayJoanna S Fowler

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