Association of DNA methylation in BDNF with escitalopram treatment response in depressed Chinese Han patients

European Journal of Clinical Pharmacology
Peipei WangWeimin Cai

Abstract

The neurotrophin brain-derived neurotrophic factor (BDNF) has been found to be associated with both the pathophysiology of depression and antidepressants response. Gene expression differences were partly mediated by SNP, which might be identified as a predictor of antidepressant response. In the present study, we attempt to identify whether DNA methylation, another factor known to affect gene transcription, might also predict antidepressant response. A total of 85 depressed Chinese Han patients were followed-up 8 weeks after initiating escitalopram treatment. Treatment response was assessed by changes in the Hamilton Depression Rating Scale-17 (HAMD-17) score. The Life Events Scale (LES) and the Childhood Trauma Questionnaire (CTQ) were utilized as the assessment of previous life stress. The bisulfate sequencing was used to assess DNA methylation. Four single nucleotide polymorphisms (SNPs) in the BDNF gene were genotyped using PCR-RFLP or PCR sequencing. We identified a DNA methylation predictor (P = 0.006-0.036) and a DNA methylation by LES interaction predictor (OR = 1.442 [1.057-1.968], P = 0.021) of general antidepressant treatment response. Lower mean BDNF DNA methylation was associated with impaired antidepressant respon...Continue Reading

References

Dec 14, 2002·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Michael BauerUNKNOWN World Federation of Societies Biological Psychiatry Task Force on Treatment Guidelines for Unipolar Depressive Disorders
Apr 23, 2003·Biological Psychiatry·Maurizio Fava
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Sep 30, 2003·The American Journal of Psychiatry·Greer M MurphyAlan F Schatzberg
Jan 5, 2006·The American Journal of Psychiatry·Kenneth S KendlerNancy L Pedersen
Jan 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Andrea DaneseRichie Poulton
Apr 25, 2007·Nature Reviews. Neuroscience·Nadia TsankovaEric J Nestler
Oct 17, 2008·Nature·Vaishnav Krishnan, Eric J Nestler
Jul 1, 2009·Pharmacology & Therapeutics·Sonja Horstmann, Elisabeth B Binder
Sep 2, 2009·Neuropsychiatric Disease and Treatment·Yogesh Dwivedi
Dec 17, 2009·Molecular Psychiatry·E B Binder, C B Nemeroff
Oct 26, 2010·Endocrine Reviews·Z HochbergK Albertsson-Wikland
Dec 17, 2010·Expert Review of Neurotherapeutics·Robert Keers, Katherine J Aitchison
Dec 22, 2010·Journal of Psychiatry & Neuroscience : JPN·Stefano PorcelliAlessandro Serretti
Mar 13, 2012·Pharmacological Reviews·Anita E Autry, Lisa M Monteggia
Mar 23, 2012·The International Journal of Neuropsychopharmacology·Katharina DomschkeJürgen Deckert
May 18, 2013·BMC Medicine·Uzoezi OzomaroCharles B Nemeroff
Aug 3, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Katharina DomschkeJürgen Deckert
Oct 25, 2013·International Review of Psychiatry·Helge Frieling, André Tadić
Dec 21, 2013·British Journal of Clinical Pharmacology·Gavin P ReynoldsCaroline F Dalton
Mar 25, 2014·Journal of Psychiatric Research·Satoshi OkadaMasaru Mimura
Apr 1, 2014·The International Journal of Neuropsychopharmacology·Katharina DomschkeBernhard T Baune
May 9, 2014·Journal of Neural Transmission·Katharina DomschkeBernhard T Baune
Jan 23, 2016·Clinical Epigenetics·Rosie May WalkerKathryn Louise Evans
Dec 28, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Patricia GassóSergi Mas
Feb 6, 2017·Clinical Epigenetics·Mihoko Shimada-SugimotoTsukasa Sasaki
Jul 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Thomas W McDadeChristopher W Kuzawa

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Citations

Jul 25, 2020·Epigenomics·Bernardo J KrauseJames Hamilton
Feb 6, 2020·International Journal of Molecular Sciences·Lauren M WebbCaren J Blacker
Sep 29, 2019·Journal of Psychiatric Research·Julia TomasiArun K Tiwari
Feb 23, 2020·Neuroscience and Biobehavioral Reviews·Charlotte A M CecilTobias Nolte
Feb 26, 2019·Journal of Affective Disorders·Laura M HackBoadie W Dunlop
Dec 2, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Helene A FachimGavin P Reynolds
Apr 29, 2021·Pharmacogenomics and Personalized Medicine·Albert Martinez-PinteñoSergi Mas
Aug 6, 2021·Acta Neuropsychiatrica·Amanda J SalesSâmia R L Joca

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Methods Mentioned

BETA
pharmacotherapy
PCR
Amplicon Sequencing

Software Mentioned

Shesis
SPSS®

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