Association of DNA repair and xenobiotic pathway gene polymorphisms with genetic susceptibility to gastric cancer patients in West Bengal, India

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Soumee GhoshMadhusudan Das

Abstract

Gastric cancer is one of the most common malignancies in India. DNA repair gene or xenobiotic pathway gene polymorphisms have recently been shown to affect individual susceptibility to gastric cancer. Here, the possible interaction between common polymorphisms in X-ray repair cross complementing group I (XRCC1) gene and glutathione S-transferase (GST) genes (GSTM1, GSTT1 and GSTP1), smoking and alcohol consumption and overall survival in gastric cancer patients were evaluated. In this population-based case control study, 70 gastric cancer patients and 82 healthy controls were enrolled. The epidemiological data were collected by a standard questionnaire, and blood samples were collected from each individual. XRCC1 Arg194Trp, Arg280His and Arg399Gln polymorphisms were determined by polymerase chain reaction and direct DNA sequencing. GSTM1 and GSTT1 null polymorphisms and GSTP1 Ile105Val polymorphism were identified by multiplex polymerase chain reaction and restriction fragment length polymorphism (RFLP), respectively. The risk of gastric cancer was significantly elevated in individuals with XRCC1 Arg/Gln +Gln/Gln (p = 0.031; odds ratio = 2.32; 95 % confidence interval (CI) 1.07-5.06) and GSTP1 Val/Val genotype (p = 0.009; odds ...Continue Reading

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Citations

Aug 11, 2018·Environmental and Molecular Mutagenesis·Zareen SultanaMadhusudan Das
Apr 4, 2018·Updates in Surgery·Chandramohan Servarayan MurugesanJayanthi Venkataraman
Jan 8, 2021·Chemico-biological Interactions·Wenting DengYawei Zhang
Apr 20, 2021·Indian Journal of Clinical Biochemistry : IJCB·Raju Kumar Mandal, Rama Devi Mittal

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