Association of DNA repair gene XRCC1 polymorphisms with head and neck cancer in Korean population

International Journal of Cancer. Journal International Du Cancer
Kyung TaeHyoung Doo Shin

Abstract

Squamous cell carcinoma of the head and neck (SCCHN), which is relatively prevalent in Korea, is believed to be induced by environmental carcinogens and host genetic factors. Accumulating evidence has shown that genetic differences in DNA repair capacity resulting from genetic polymorphism influence the risk of environmental carcinogenesis. We therefore examined the associations of genetic polymorphisms in the DNA repair genes XRCC1 with the risk of SCCHN in a Korean population (hospital-based, case-control study; 147 cases and 168 controls). Three known polymorphisms in the XRCC1 gene were genotyped: R194W(C>T) in exon 6, R280H(G>A) in exon 9 and R399G(G>A) in exon 10. Although no significant associations were apparent with R280H(G>A) and R399G(G>A), a highly significant association (p = 0.0005) of R194W(C>T) with the increased risk (OR = 2.61; 95% CI 1.53-4.46) of SCCHN was detected among patients and normal controls under dominant model. The frequency of minor allele-containing genotypes (TT and CT) was much higher in SCCHN patients (51.8%) compared to that in normal controls (30.3%) (p = 0. 0005). When considering a relatively small number of cases (n = 147) and controls (n = 168) in our study, larger studies are needed to ...Continue Reading

References

Jan 1, 1994·Molecular and Cellular Biology·K W CaldecottL H Thompson
Jun 19, 1993·International Journal of Cancer. Journal International Du Cancer·D M ParkinJ Ferlay
Sep 21, 1996·BMJ : British Medical Journal·W D FoulkesS A Narod
Feb 5, 1998·CA: a Cancer Journal for Clinicians·S H LandisP A Wingo
Aug 1, 2000·Mutation Research·A Memisoglu, L Samson
Mar 20, 2001·American Journal of Human Genetics·M StephensP Donnelly
Apr 4, 2001·Carcinogenesis·D ButkiewiczC C Harris
Jun 16, 2001·International Journal of Cancer. Journal International Du Cancer·J M LeeM T Wu
Nov 7, 2001·The American Journal of Pathology·S L HolleyP R Hoban
Feb 28, 2002·Cancer Letters·Andrew F OlshanDouglas A Bell
Jul 19, 2002·International Journal of Cancer. Journal International Du Cancer·Deyin XingDongxin Lin
Feb 18, 2003·Journal of Korean Medical Science·Kwang-Moon KimUNKNOWN Study Group of Korean Society of Head and Neck Surgeons

❮ Previous
Next ❯

Citations

May 18, 2005·Cancer Detection and Prevention·Tianli Qu, Kanehisa Morimoto
May 4, 2005·Nucleic Acids Research·Reto Brem, Janet Hall
Jan 1, 2011·Pharmacogenomics and Personalized Medicine·Alec VaeziLaura J Niedernhofer
Jun 29, 2011·Genetics and Molecular Research : GMR·A C CustódioC Casartelli
May 31, 2013·Journal of Biomedical Research·Meilin WangQingyi Wei
Jul 30, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yan-Zhong FengDao-Lin Xie
Jul 27, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xue ZhouChuan Liu
Dec 24, 2013·International Journal of Genomics·Glenn JenkinsDerek J Richard
May 25, 2010·Cancer Biology & Therapy·Rui GaoWilliam D Figg
Jul 4, 2016·Journal of Cancer Research and Clinical Oncology·Ericka Francislaine Dias CostaGustavo Jacob Lourenço
Jan 2, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Hiroshi HirataRajvir Dahiya
Dec 24, 2005·International Journal of Hygiene and Environmental Health·Suparp KietthubthewTakafumi Ishida
Jun 24, 2008·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Adriana Báez
Aug 24, 2011·Journal of Korean Medical Science·Ri A RyuYou Hern Ahn
Jul 2, 2010·Journal of Korean Medical Science·Seung Won JeongHyoung Doo Shin
Apr 10, 2010·Clinical and Experimental Otorhinolaryngology·Yong Bae JiHyoung Doo Shin
Apr 16, 2008·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Ching-Yu YenHsueh-Wei Chang
Feb 21, 2009·International Journal of Cancer. Journal International Du Cancer·Katie M ApplebaumKarl T Kelsey
Sep 12, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Rim KhlifiAhmed Rebai
May 1, 2010·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Rafael E Flores-ObandoCamille C Ragin
Feb 10, 2007·International Journal of Cancer. Journal International Du Cancer·Mousumi MajumderBidyut Roy
Oct 2, 2012·Human & Experimental Toxicology·B KarahalilD M Wilson
Nov 19, 2011·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Sanjit MukherjeeKeya Chaudhuri
Apr 16, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yong Bae JiKyung Tae

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Cancer Letters
Andrew F OlshanDouglas A Bell
Pathology Oncology Research : POR
Semra DemokanNejat Dalay
Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Biyun QianKexin Chen
European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
M Kostrzewska-PoczekajKrzysztof Szyfter
© 2022 Meta ULC. All rights reserved