Association of dose escalation of octreotide long-acting release on clinical symptoms and tumor markers and response among patients with neuroendocrine tumors

Cancer Medicine
Khalid Al-EfraijHagen Fritz Kennecke

Abstract

Patients with nonresectable metastatic neuroendocrine tumors (NETs) experience symptoms of hormone hypersecretion including diarrhea, flushing, and bronchoconstriction, which can interfere with quality of life [Anthony and Vinik (2011) Pancreas, 40:987]. Treatment with a long-acting release formulation of octreotide, a somatostatin analog, can help to alleviate these symptoms. Although high doses of octreotide are often required for adequate symptom control, the relationship between octreotide dose escalation and symptom control in the NET context is not well quantified in the literature. A retrospective chart review was conducted of nonresectable metastatic NET patients who received a dose greater than 30 mg intramuscular octreotide long-acting formulation (O-LAR) at any time between January 2005 and December 2011 at the British Columbia Cancer Agency (BCCA). The association between dose escalation of O-LAR, chromogranin A (CGA), 24-h urine 5-hydoxyindoacetate (5-HIAA), symptom control, and radiological progression was explored. Dose escalation of O-LAR was associated with improved symptom control in NET patients who were refractory to the standard dose levels. Reduction of serum CGA & 5-HIAA levels by at least 10% was observe...Continue Reading

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Citations

Aug 8, 2018·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Beloo MirakhurAaron I Vinik
Jan 5, 2019·Endocrine-related Cancer·Johannes HoflandWouter W de Herder
Jul 10, 2019·Current Treatment Options in Oncology·Kira OleinikovSimona Grozinsky-Glasberg
May 1, 2019·AJR. American Journal of Roentgenology·A Tuba KendiRathan M Subramaniam
Nov 10, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Tetsuhide ItoRobert T Jensen
Apr 25, 2019·The Oncologist·Andrew J KlinkAaron Vinik
Sep 19, 2017·Current Oncology Reports·Alberto Carmona-BayonasUNKNOWN Spanish Neuroendocrine Tumor Group (GETNE)
Feb 17, 2017·Therapeutic Advances in Medical Oncology·Rachel P RiechelmannFrederico P Costa
Jun 27, 2019·International Journal of Molecular Sciences·Anna Kathrin StuevenHenning Jann
Aug 6, 2020·Journal of Clinical Medicine·Sara PuscedduFilippo de Braud
Nov 8, 2016·Expert Opinion on Pharmacotherapy·Angela LamarcaJuan W Valle
Sep 4, 2020·World Journal of Gastrointestinal Oncology·Gabriel Antonio RobertoRiad Naim Younes
Feb 5, 2021·Journal of Clinical Medicine·Maria Celeste CantoneGiovanni Vitale

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Methods Mentioned

BETA
surgical resection

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