Association of down-regulation of cytokine activity with rat hind limb allograft survival

Transplantation
M J FealyB H Press

Abstract

Cytokines are short-acting protein modulators of many physiologic processes including graft rejection. An understanding of the production, action, and interaction of cytokines may lead to better appreciation of the complex mechanism of graft rejection. The potential would then exist for more selective and less-toxic means of modulating the immune response. A rat hind limb allograft model with major immunohistoincompatibility was used to study the local mRNA expression of IL-1 alpha, IL-2, IL-6, gamma interferon (gamma INF), platelet-derived growth factor-alpha (PDGF-alpha), basic fibroblast growth factor (FGF), and transforming growth factor-beta (TGF-beta) during acute allograft rejection. A 14-day postoperative course of immunosuppressive therapy with FK506 or rapamycin was administered. In situ hybridization was performed on serial full-thickness skin punch biopsies of the untreated rejecting limb allograft and compared with tissue from treated allografts, isografts, and to normal limb tissue. A sequential pattern of cytokine mRNA expression was demonstrated which progressed in a time-dependent manner and paralleled observed clinical rejection. Maximal cytokine mRNA expression correlated with peak graft rejection. Cellular e...Continue Reading

Citations

May 2, 1997·International Journal of Cancer. Journal International Du Cancer·M Landström, K Funa
Sep 24, 1998·Transplantation Proceedings·A Zeevi
Sep 24, 1998·Transplantation Proceedings·M V ShirbachehS A Gruber
May 10, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·H A de Groot-KrusemanW Weimar
Jun 5, 2002·Plastic and Reconstructive Surgery·Terence M MyckatynSusan E Mackinnon
Feb 16, 2000·The Tohoku Journal of Experimental Medicine·T AbeM Tamai

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