Association of Drinking Problems and Duration of Alcohol Use to Inhibitory Control in Nondependent Young Adult Social Drinkers

Alcoholism, Clinical and Experimental Research
Sien HuChiang-Shan Ray Li

Abstract

Deficits in inhibitory control have been widely implicated in alcohol misuse. However, the literature does not readily distinguish the effects of drinking problems and chronic alcohol use. Here, we examined how years of drinking and the Alcohol Use Disorders Identification Test (AUDIT) score each influences the cerebral responses to inhibitory control in nondependent drinkers. Fifty-seven adult drinkers and 57 age- and gender-matched nondrinkers participated in one 40-minute functional magnetic resonance imaging scan of the stop signal task. Data were preprocessed and modeled using SPM8. In a regression model, we contrasted stop and go success trials for individuals and examined activities of response inhibition each in link with the AUDIT score and years of alcohol use in group analyses. We specified the effects of duration of use by contrasting regional activations of drinkers and age-related changes in nondrinkers. In mediation analyses, we investigated how regional activities mediate the relationship between drinking problems and response inhibition. Higher AUDIT score but not years of drinking was positively correlated with prolonged stop signal reaction time (SSRT) and diminished responses in the cerebellum, thalamus, fro...Continue Reading

References

Dec 12, 2003·Addictive Behaviors·Susan F TapertSandra A Brown
Jun 1, 2005·Biological Psychology·Chella KamarajanHenri Begleiter
Sep 14, 2006·Annual Review of Psychology·David P MacKinnonMatthew S Fritz
Jun 11, 2008·Alcoholism, Clinical and Experimental Research·Andrea D SpadoniSusan F Tapert
Jul 18, 2008·Alcoholism, Clinical and Experimental Research·Gabriel RubioTomás Palomo
Jan 28, 2009·Alcoholism, Clinical and Experimental Research·Chiang-Shan Ray LiRajita Sinha
Feb 3, 2009·Alcoholism, Clinical and Experimental Research·Katrijn Houben, Reinout W Wiers
Jun 26, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Robert HesterHugh Garavan
Mar 6, 2010·Alcoholism, Clinical and Experimental Research·Sabine Vollstädt-KleinKarl Mann
May 25, 2010·Alcoholism, Clinical and Experimental Research·Helen C FoxSinha Rajita
Sep 4, 2010·International Review of Neurobiology·Kenneth AbernathyJohn J Woodward
Dec 15, 2010·Drug and Alcohol Dependence·Philip Murphy, Hugh Garavan
Mar 29, 2011·Frontiers in Human Neuroscience·Jaime S Ide, Chiang-Shan R Li
Jun 3, 2011·Alcoholism, Clinical and Experimental Research·Daniel M BlonigenRudolf H Moos
Oct 7, 2011·Human Brain Mapping·Sien Hu, Chiang-Shan R Li
Jan 19, 2012·Alcoholism, Clinical and Experimental Research·Anita Cservenka, Bonnie J Nagel
Feb 22, 2012·Alcoholism, Clinical and Experimental Research·Sarah R BednarskiChiang-Shan R Li
Mar 20, 2012·Drug and Alcohol Dependence·Margarita MorenoPilar Flores
Apr 27, 2012·Frontiers in Aging Neuroscience·Sien HuChiang-Shan R Li
Aug 28, 2012·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Alissa D WinklerChiang-shan R Li
Dec 4, 2012·Journal of Studies on Alcohol and Drugs·Eric D ClausKent E Hutchison
May 15, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Aral AhmadiMichael C Stevens
Jul 31, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Julia F van den BergHannie C Comijs
Oct 15, 2013·Alcoholism, Clinical and Experimental Research·Robert F LeemanChristopher W Kahler
Nov 22, 2013·JAMA Psychiatry·Scott J MoellerRita Z Goldstein
Feb 12, 2014·Alcoholism, Clinical and Experimental Research·Marisa M SilveriJennifer T Sneider
Mar 19, 2014·Developmental Cognitive Neuroscience·Lindsay M SquegliaSusan F Tapert
Jun 26, 2014·Alcoholism, Clinical and Experimental Research·Yasmin MashhoonMarisa M Silveri
Nov 20, 2014·Alcoholism, Clinical and Experimental Research·Ashley AchesonDonald M Dougherty
Dec 24, 2014·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·David R FoxcroftSarah Howcutt
May 9, 2015·Frontiers in Human Neuroscience·Jianping QiaoChristina W Hoven

❮ Previous
Next ❯

Citations

Jan 5, 2018·Brain Sciences·Sean M MolnarKsenija Marinkovic

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.