Association of Dysanapsis With Chronic Obstructive Pulmonary Disease Among Older Adults.

JAMA : the Journal of the American Medical Association
Benjamin M SmithMESA Lung, CanCOLD, and SPIROMICS Investigators

Abstract

Smoking is a major risk factor for chronic obstructive pulmonary disease (COPD), yet much of COPD risk remains unexplained. To determine whether dysanapsis, a mismatch of airway tree caliber to lung size, assessed by computed tomography (CT), is associated with incident COPD among older adults and lung function decline in COPD. A retrospective cohort study of 2 community-based samples: the Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study, which involved 2531 participants (6 US sites, 2010-2018) and the Canadian Cohort of Obstructive Lung Disease (CanCOLD), which involved 1272 participants (9 Canadian sites, 2010-2018), and a case-control study of COPD: the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS), which involved 2726 participants (12 US sites, 2011-2016). Dysanapsis was quantified on CT as the geometric mean of airway lumen diameters measured at 19 standard anatomic locations divided by the cube root of lung volume (airway to lung ratio). Primary outcome was COPD defined by postbronchodilator ratio of forced expired volume in the first second to vital capacity (FEV1:FVC) less than 0.70 with respiratory symptoms. Secondary outcome was longitudinal lung function. All analyses were adjusted...Continue Reading

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Citations

Aug 18, 2020·Radiology·Mark L Schiebler, Sean Fain
Oct 21, 2020·JAMA : the Journal of the American Medical Association·Chika Edward Uzoigwe
Oct 21, 2020·JAMA : the Journal of the American Medical Association·Benjamin M SmithR Graham Barr
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Nov 3, 2020·American Journal of Respiratory and Critical Care Medicine·Motahareh VameghestahbanatiBenjamin M Smith
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Jan 8, 2021·Frontiers in Physiology·Naoya TanabeToyohiro Hirai
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Mar 30, 2021·ERJ Open Research·Naoya TanabeToyohiro Hirai
May 2, 2021·Acta Paediatrica·Matti Korppi, Riikka Riikonen
Apr 9, 2021·American Journal of Respiratory and Critical Care Medicine·Emiel F M Wouters
Aug 16, 2021·Chest·Motahareh VameghestahbanatiEric A Hoffman
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