Association of E-cadherin (CDH1) gene polymorphisms and gastric cancer risk.

World Journal of Gastroenterology : WJG
Mansour S Al-MoundhriBassim Al-Bahrani

Abstract

To investigate the associations between CDH1 gene polymorphisms and gastric cancer (GC) risk predisposition. We analyzed four CDH1 polymorphisms (+54 T>C, -160 C>A, -616 G>C, -3159 T>C) in an Omani population, by extraction of genomic DNA from the peripheral blood of 192 patients with GC and 170 control participants and performed CDH1 genotyping using DNA sequencing. CDH1 -160 -AA genotype was associated with an increased risk of GC (OR = 3.6, 95% CI: 1.1-11.8) (P = 0.03). There was no significant association between the other polymorphisms and GC risk. The haplotype analysis of +54 T>C, -160 C>A, -616 G>C, -3159 T>C genotypes revealed that the OR of CCGC and CAGC haplotypes was 1.5 (95% CI: 0.7-3.5) and 1.5 (95% CI: 0.2-3.0), but did not reach statistical significance. The current study suggests that the -160 AA genotype was associated with an increased risk of GC in Oman.

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Citations

Oct 15, 2011·International Journal of Colorectal Disease·Yadong WangXiangqun Xia
May 27, 2011·DNA and Cell Biology·Yun CuiJing-Yuan Fang
Oct 3, 2014·Molecular Biology International·Gongcheng LiLong-Cheng Li
Oct 22, 2017·Nephrology·Haidar Ahmed ShamranElham Ahmed Jasim
May 30, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Qi-Wen DengShu-Kui Wang
Sep 11, 2014·World Journal of Gastroenterology : WJG·Danilo do Rosário PinheiroBárbara do Nascimento Borges
Jun 5, 2021·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Ramin ShekarrizMohammad Bagher Hashemi-Soteh
Aug 24, 2021·Frontiers in Molecular Biosciences·Huichen ZhaoXiao-Bing Chen

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