Abstract
To investigate the associations between CDH1 gene polymorphisms and gastric cancer (GC) risk predisposition. We analyzed four CDH1 polymorphisms (+54 T>C, -160 C>A, -616 G>C, -3159 T>C) in an Omani population, by extraction of genomic DNA from the peripheral blood of 192 patients with GC and 170 control participants and performed CDH1 genotyping using DNA sequencing. CDH1 -160 -AA genotype was associated with an increased risk of GC (OR = 3.6, 95% CI: 1.1-11.8) (P = 0.03). There was no significant association between the other polymorphisms and GC risk. The haplotype analysis of +54 T>C, -160 C>A, -616 G>C, -3159 T>C genotypes revealed that the OR of CCGC and CAGC haplotypes was 1.5 (95% CI: 0.7-3.5) and 1.5 (95% CI: 0.2-3.0), but did not reach statistical significance. The current study suggests that the -160 AA genotype was associated with an increased risk of GC in Oman.
References
May 24, 1997·Lancet·C J Murray, A D Lopez
Oct 19, 2001·Gastroenterology·E M El-OmarC S Rabkin
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Carlos A GonzálezGabriel Capellá
Sep 5, 2002·International Journal of Cancer. Journal International Du Cancer·Paul D P PharoahDavid Huntsman
Nov 22, 2002·Oncogene·Bostjan HumarParry Guilford
Feb 19, 2003·Journal of Clinical Epidemiology·Jon R Kelley, John M Duggan
May 17, 2005·Journal of Surgical Oncology·Pelayo Correa
May 17, 2005·Journal of Surgical Oncology·Henry T LynchDavid Huntsman
Aug 17, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Pelayo Correa, Barbara G Schneider
Sep 14, 2007·Scandinavian Journal of Gastroenterology·Hidetaka YamadaHaruhiko Sugimura
Nov 1, 2007·American Journal of Epidemiology·Gui-Ying WangZ W Luo
Jan 17, 2008·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·X-F ZhangJ-H Zhang
Jun 12, 2008·Alimentary Pharmacology & Therapeutics·L GaoH Brenner
Dec 17, 2008·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Giovanni CorsoFranco Roviello
Citations
Oct 15, 2011·International Journal of Colorectal Disease·Yadong WangXiangqun Xia
Dec 24, 2011·Endocrine·Ying-Xue WangSu-Guo Yu
Jan 19, 2011·ACS Chemical Biology·Sydney L StoopsCraig W Lindsley
May 27, 2011·DNA and Cell Biology·Yun CuiJing-Yuan Fang
Jul 14, 2012·PloS One·Lin WangJiuhong Kang
Apr 2, 2014·World Journal of Surgical Oncology·Chi-Ming ChuMing-Hsin Yang
Oct 24, 2014·Medicine·Huiquan JingJingyun Yang
Jan 21, 2015·Scientific Reports·Benchun JiangWei Sun
May 17, 2011·Cytokine·Bo ChenXiao-Ting Wu
Oct 3, 2014·Molecular Biology International·Gongcheng LiLong-Cheng Li
Apr 6, 2017·BMC Medical Genetics·Renato Assis MachadoHercílio Martelli-Júnior
Oct 22, 2017·Nephrology·Haidar Ahmed ShamranElham Ahmed Jasim
May 30, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Qi-Wen DengShu-Kui Wang
Sep 11, 2014·World Journal of Gastroenterology : WJG·Danilo do Rosário PinheiroBárbara do Nascimento Borges
Nov 3, 2014·Open Medicine·Yijin LinHong Zhao
Apr 27, 2012·Molecular Biology Reports·Zhen ZhanWei Dong
May 29, 2018·Environmental Science and Pollution Research International·Marina RéquiléHafida Khorsi-Cauet
Jun 5, 2021·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Ramin ShekarrizMohammad Bagher Hashemi-Soteh
Aug 24, 2021·Frontiers in Molecular Biosciences·Huichen ZhaoXiao-Bing Chen