Association of echocardiographic atrial size and atrial fibrosis in a sequential model of congestive heart failure and atrial fibrillation

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
Christian KnackstedtPatrick Schauerte

Abstract

Cardioversion (CV) success of atrial fibrillation (AF) inversely correlates to the size of the left atrium (LA). Atrial fibrillation and its most important risk factor, congestive heart failure (CHF), both induce atrial structural enlargement and fibrosis. To investigate the effect of AF and CHF on atrial dilatation and fibrosis, and to estimate whether echocardiographically determined atrial size may be used as a marker for atrial fibrosis. In six dogs, pacemakers were implanted followed by HIS bundle ablation. After 4 weeks of rapid ventricular stimulation (185 bpm) for CHF induction, additional rapid atrial stimulation (500 bpm) was maintained for 7 weeks to induce AF. Serial determinations of echocardiographic atrial size were performed. Seven dogs with sinus rhythm served as histological controls. Postmortem tissue was obtained to determine the degree and composition of atrial fibrosis. While the ejection fraction of the AF/CHF dogs decreased significantly from 57+/-5% to 19+/-7% (P<.01), an increased degree of atrial fibrosis was found (right atrium [RA], 4.9+/-2.0% to 19.9+/-5.4%; LA, 4.4+/-1.6% to 22.2+/-3.2%; P<.01), accompanied by a significant increase of atrial volumes (LA: 21+/-4 to 44+/-4 mm3; P<.01; RA: 10+/-3 to...Continue Reading

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Citations

Jun 15, 2011·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Sotirios NediosCharalampos Kriatselis
Feb 24, 2009·Age·Felix GramleyPatrick Schauerte
Jan 13, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Marcelle D SmitIsabelle C Van Gelder
Oct 14, 2011·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Eivind SolheimJian Chen
Sep 27, 2014·Current Heart Failure Reports·Christina LuongTeresa S M Tsang
Nov 5, 2011·Heart Failure Reviews·Pedram KazemianBodh I Jugdutt
Oct 30, 2012·Clinics in Geriatric Medicine·Mahek MirzaArshad Jahangir
Sep 16, 2009·Journal of Molecular and Cellular Cardiology·Jason PellmanFarah Sheikh
Aug 22, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Jagmeet P Singh, Fred Morady
Sep 4, 2010·Journal of Cardiovascular Electrophysiology·Domenico CorradiSergio Callegari
Nov 19, 2013·Journal of Cardiovascular Electrophysiology·Owen Obel, Jose A Joglar
Aug 1, 2015·BioMed Research International·Michele Miragoli, Alexey V Glukhov
Jun 12, 2016·Journal of the American Society of Hypertension : JASH·Qian LiuQijun Shan
Jan 25, 2018·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Kang AnMin Tang
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Sep 16, 2020·Journal of Molecular and Cellular Cardiology·Stephanie A LegereUNKNOWN IMPART Investigator Team Canada

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