PMID: 9550156Apr 29, 1998Paper

Association of ecto-5'-nucleotidase with specific cell types in the adult and developing rat olfactory organ

The Journal of Comparative Neurology
N Braun, Herbert Zimmermann

Abstract

A unique feature of the olfactory epithelium is its ability to give rise to new sensory neurons throughout life and also following injury. Cells at the basal side of the epithelium serve as neurogenic progenitor cells. The enzyme ecto-5'-nucleotidase is expressed at the surface of developing nerve cells and is regarded as a marker of neural development. To study the expression pattern of the enzyme, we analyzed its distribution in the adult and developing rat olfactory organ. Labeling is restricted to specific cell types and varies between the epithelia investigated. At the basal side of the olfactory epithelium, activity of 5'-nucleotidase is associated specifically with the dark/horizontal basal cells. Neither the light/globose basal cells, which are the immediate precursors of the sensory receptor cells, nor subsets of potentially immature olfactory receptor cells are labeled. On the other hand, microvillar cells dispersed at the lumenal side of the epithelium contain 5'-nucleotidase activity. The enzyme is also present at the inner lining of the ducts of Bowman's glands as they traverse the epithelium. Within the respiratory epithelium, activity of 5'-nucleotidase is associated with basal cells as well as with the epithelia...Continue Reading

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Citations

Feb 16, 2011·Seminars in Cell & Developmental Biology·Herbert Zimmermann
Jan 18, 2006·The International Journal of Biochemistry & Cell Biology·Julio C Morote-GarcíaEncarnación Muñoz-Delgado
Oct 21, 2010·The European Journal of Neuroscience·Colleen C HeggAnne Hansen
Dec 14, 2011·Molecular and Cellular Neurosciences·Cuihong Jia, Colleen Cosgrove Hegg
Nov 9, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Giana de Paula CognatoCarla Denise Bonan
Dec 24, 2005·Journal of Neurocytology·Rebecca Elsaesser, Jacques Paysan
Sep 29, 2000·Pharmacology & Therapeutics·J Spychala

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