Association of elevated inflammatory markers and severe COVID-19: A meta-analysis.

Medicine
Pan JiJianfeng Zhang

Abstract

Our study aimed to assess the existing evidence on whether severe coronavirus disease 2019 (COVID-19) is associated with elevated inflammatory markers.The PubMed, Embase, Web of Science, Scopus, Chinese National Knowledge Infrastructure, WanFang, and China Science and Technology Journal databases were searched to identify studies published between January 1 and April 21, 2020 that assayed inflammatory markers in COVID-19 patients. Three reviewers independently examined the literature, extracted relevant data, and assessed the risk of publication bias before including the meta-analysis studies.Fifty-six studies involving 8719 COVID-19 patients were identified. Meta-analysis showed that patients with severe disease showed elevated levels of white blood cell count (WMD: 1.15, 95% CI: 0.78-1.52), C-reactive protein (WMD: 38.85, 95% CI: 31.19-46.52), procalcitonin (WMD: 0.08, 95% CI: 0.06-0.11), erythrocyte sedimentation rate (WMD: 10.15, 95% CI: 5.03-15.46), interleukin-6 (WMD: 23.87, 95% CI: 15.95-31.78), and interleukin-10 (WMD: 2.12, 95% CI: 1.97-2.28). Similarly, COVID-19 patients who died during follow-up showed significantly higher levels of white blood cell count (WMD: 4.11, 95% CI: 3.25-4.97), C-reactive protein (WMD: 74.18...Continue Reading

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Citations

Feb 14, 2021·Internal and Emergency Medicine·Alessandro RussoGabriella d'Ettorre
Feb 13, 2021·Frontiers in Medicine·Angelo Zinellu, Arduino A Mangoni
Mar 7, 2021·Journal of Clinical Medicine·Luis Sanchez-RussoPaolo Cravedi
Apr 21, 2021·Expert Review of Clinical Immunology·Nicola PotereAldo Bonaventura
Apr 28, 2021·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Panagiotis DrakosSima Mofakham
Apr 20, 2021·EBioMedicine·Manuel Castro de MouraManel Esteller
May 25, 2021·Immunological Reviews·Alison E JohnAmanda L Tatler
Jul 15, 2021·Curēus·Gregory ToppDanielle Wales
Aug 3, 2021·Critical Care Research and Practice·Juan Carlos Ruiz-RodríguezRicard Ferrer
Aug 14, 2021·The American Journal of Cardiology·Brian C CaseRon Waksman
Sep 1, 2021·Journal of the American College of Nutrition·Mohamed Ben-EltrikiSubrata Deb
Oct 9, 2021·International Journal of Laboratory Hematology·Alexandra MyariChristina Tsaousi
Oct 13, 2021·International Journal of Clinical Practice·Aslıhan Gürün KayaAkın Kaya

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