Abstract
Our study aimed to assess the existing evidence on whether severe coronavirus disease 2019 (COVID-19) is associated with elevated inflammatory markers.The PubMed, Embase, Web of Science, Scopus, Chinese National Knowledge Infrastructure, WanFang, and China Science and Technology Journal databases were searched to identify studies published between January 1 and April 21, 2020 that assayed inflammatory markers in COVID-19 patients. Three reviewers independently examined the literature, extracted relevant data, and assessed the risk of publication bias before including the meta-analysis studies.Fifty-six studies involving 8719 COVID-19 patients were identified. Meta-analysis showed that patients with severe disease showed elevated levels of white blood cell count (WMD: 1.15, 95% CI: 0.78-1.52), C-reactive protein (WMD: 38.85, 95% CI: 31.19-46.52), procalcitonin (WMD: 0.08, 95% CI: 0.06-0.11), erythrocyte sedimentation rate (WMD: 10.15, 95% CI: 5.03-15.46), interleukin-6 (WMD: 23.87, 95% CI: 15.95-31.78), and interleukin-10 (WMD: 2.12, 95% CI: 1.97-2.28). Similarly, COVID-19 patients who died during follow-up showed significantly higher levels of white blood cell count (WMD: 4.11, 95% CI: 3.25-4.97), C-reactive protein (WMD: 74.18...Continue Reading
References
May 2, 2000·JAMA : the Journal of the American Medical Association·D F StroupS B Thacker
Apr 21, 2005·BMC Medical Research Methodology·Stela Pudar HozoIztok Hozo
Jun 20, 2006·Shock·Peter FraunbergerDietrich Seidel
Jul 24, 2010·European Journal of Epidemiology·Andreas Stang
Jul 12, 2013·PloS One·Hong-Shiee LaiPo-Huang Lee
Feb 21, 2014·Seminars in Immunology·Koji Taniguchi, Michael Karin
Mar 22, 2018·The Journal of Biological Chemistry·Paul BaranJürgen Scheller
Jan 28, 2020·Lancet·Chaolin HuangBin Cao
Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng
Feb 23, 2020·Allergy·Jin-Jin ZhangYa-Dong Gao
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 3, 2020·Chinese Medical Journal·Wei LiuYi Hu
Mar 8, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Giuseppe Lippi, Mario Plebani
Mar 15, 2020·Lancet·Fei ZhouBin Cao
Mar 17, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Jing YangYongning Zhou
Mar 18, 2020·Journal of Medical Virology·Yong GaoLinding Wang
Mar 22, 2020·Journal of Medical Virology·Suxin WanRuishan Yang
Mar 27, 2020·Chinese Medical Journal·Yan DengHui-Guo Liu
Mar 29, 2020·BMJ : British Medical Journal·Tao ChenQin Ning
Apr 3, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Hansheng XieHuichang Zhuo
Apr 3, 2020·Allergy·Qingxian CaiJun Chen
Apr 3, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Yafei ZhangQiu Zhao
Apr 3, 2020·The Journal of Infection·Lang WangHong Jiang
Apr 8, 2020·Intensive Care Medicine·Wen-Jun TuQiang Liu
Apr 8, 2020·Médecine et maladies infectieuses·Zulvikar Syambani Ulhaq, Gita Vita Soraya
Apr 9, 2020·American Journal of Respiratory and Critical Care Medicine·Yang WangJun Wang
Apr 11, 2020·American Journal of Respiratory and Critical Care Medicine·Yun FengJieming Qu
Apr 14, 2020·Journal of Medical Virology·Chaochao TanXiaosong Li
Apr 17, 2020·British Journal of Haematology·Suxin WanCailiang Gao
Apr 17, 2020·The Journal of Infection·Jia MaYuan Wu
Apr 18, 2020·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Yongli ZhengDan Wang
Apr 29, 2020·Journal of Medical Virology·Muhammad AzizRagheb Assaly
May 20, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Furong ZengGuangtong Deng
Citations
Feb 14, 2021·Internal and Emergency Medicine·Alessandro RussoGabriella d'Ettorre
Feb 13, 2021·Frontiers in Medicine·Angelo Zinellu, Arduino A Mangoni
Feb 9, 2021·Heliyon·Shikha PatelPriti Mehta
Feb 10, 2021·Journal of Medical Virology·Jaya KaushikJitendra Kumar Singh Parihar
Feb 13, 2021·Diagnostics·Andrea Daniele AnnoniDaniele Andreini
Mar 7, 2021·Journal of Clinical Medicine·Luis Sanchez-RussoPaolo Cravedi
Apr 14, 2021·Medicine·Youxiang ZhengYan Zeng
Apr 21, 2021·Expert Review of Clinical Immunology·Nicola PotereAldo Bonaventura
Apr 28, 2021·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Panagiotis DrakosSima Mofakham
Apr 20, 2021·EBioMedicine·Manuel Castro de MouraManel Esteller
May 1, 2021·Life·Mohammad Moslem ImaniDena Sadeghi-Bahmani
May 25, 2021·Immunological Reviews·Alison E JohnAmanda L Tatler
Jun 3, 2021·Diseases·Ravi Philip Rajkumar
May 25, 2021·Curēus·Thomas G NgMorium Akthar
Jul 3, 2021·Medicina·Yue ShenShuaiyin Chen
Jun 14, 2021·Virology Journal·Shi-Wei YinYi Qiu
Jul 1, 2021·Anaesthesia·E H TaylorB M Biccard
Jul 15, 2021·Curēus·Gregory ToppDanielle Wales
Aug 3, 2021·Critical Care Research and Practice·Juan Carlos Ruiz-RodríguezRicard Ferrer
Aug 14, 2021·The American Journal of Cardiology·Brian C CaseRon Waksman
Aug 18, 2021·Diabetes & Metabolic Syndrome·Jayanthy RameshS L Sagar Reddy
Sep 1, 2021·Journal of the American College of Nutrition·Mohamed Ben-EltrikiSubrata Deb
Oct 9, 2021·International Journal of Laboratory Hematology·Alexandra MyariChristina Tsaousi
Oct 13, 2021·International Journal of Clinical Practice·Aslıhan Gürün KayaAkın Kaya
Oct 19, 2021·Pharmacotherapy·Kaitlin M LandolfMelissa L Thompson Bastin
Oct 23, 2021·Frontiers in Neurology·Teng J PengRicha Sharma
Nov 17, 2021·Expert Review of Endocrinology & Metabolism·Hoimonti DebiMohammad Salim Hossain