Association of ENAM, TUFT1, MMP13, IL1B, IL10 and IL1RN gene polymorphism and dental caries susceptibility in Chinese children

The Journal of International Medical Research
Xiao-Pan HuZhi-Qiang Li

Abstract

To investigate the association between single nucleotide polymorphisms (SNPs) in six candidate genes (enamelin [ ENAM]; tuftelin 1 [ TUFT1]; matrix metallopeptidase 13 [ MMP13]; interleukin 1 beta [ IL1B]; interleukin 10 [ IL10]; interleukin 1 receptor antagonist [ IL1RN]) and dental caries in children from northwest China. This case-control study enrolled children (12-15 years) who underwent routine dental examinations. The children were divided into two groups based on the presence of dental caries. A saliva sample was collected and seven SNPs (rs3806804A/G in ENAM, rs3811411T/G in TUFT1, rs2252070A/G and rs597315A/T in MMP13, rs1143627C/T in IL1B, rs1800872A/C in IL10 and rs956730G/A in IL1RN) were genotyped. A total of 357 children were enrolled in the study: 161 with dental caries and 196 without dental caries. No significant difference was found in the alleles and genotypes of five genes ( ENAM, TUFT1, MMP13, IL10 and IL1RN) between those with and without dental caries. A significant relationship was found between the IL1B rs1143627C/T polymorphism and dental caries susceptibility with those carrying the rs1143627CT genotype having a lower risk of dental caries compared with those carrying the CC genotype (odds ratio 0.55...Continue Reading

References

Apr 2, 2004·European Journal of Oral Sciences·Stephanie FanchonMichel Goldberg
Jul 26, 2005·Journal of Dental Research·R L SlaytonM L Marazita
Jan 20, 2009·Biological Psychiatry·Andrew H MillerCharles L Raison
Feb 15, 2012·Journal of Dentistry·Patricia Nivoloni TannureAlexandre Rezende Vieira
Jun 20, 2012·Caries Research·P N TannureJ M Granjeiro
Mar 27, 2015·Journal of Oral Science·Dilsah CoguluCemal Eronat
Jul 1, 2015·Genetics and Molecular Research : GMR·Z-Q LiJ-M Zhang
Sep 16, 2015·International Journal of Paediatric Dentistry·Lívia Azeredo AntunesIzabel Christina N P Paixão
Sep 18, 2015·Journal of Dental Research·G YildizG Y Türel
Feb 26, 2016·Clinical Oral Investigations·Karolina GerrethMichal Nowicki
Jul 30, 2016·The Journal of Clinical Pediatric Dentistry·Dilsah CoguluCemal Eronat
Nov 28, 2016·Caries Research·Lydie Izakovicova HollaMartina Kukletova
Nov 29, 2016·Caries Research·Yousef M AlyousefAmein K Al-Ali
Jan 20, 2017·Journal of Human Genetics·Scott EckertJohn R Shaffer
May 5, 2017·Physiological Reviews·Rodrigo S LacruzMichael L Paine
Jul 3, 2017·Caries Research·Paula Piekoszewska-ZiętekDorota Olczak-Kowalczyk

❮ Previous
Next ❯

Citations

Jul 10, 2020·Acta Odontologica Scandinavica·Caio Luiz Bitencourt ReisDaniela Silva Barroso de Oliveira
May 14, 2020·BMC Oral Health·Petra Borilova LinhartovaLydie Izakovicova Holla
Sep 15, 2019·Histochemistry and Cell Biology·Jan BobekEva Matalova

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

SPSS®
MassARRAY®
AssayDesigner3

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.