Association of endothelial nitric oxide synthase genotypes with bone mineral density, bone loss, hip structure, and risk of fracture in older women: the SOF study

Bone
Brent C TaylorSOF Research Group

Abstract

Nitric oxide (NO) is an important bone-signaling molecule. We examined the associations between the Glu298Asp polymorphism of NOS3, indices of bone strength, and the incidence of fracture among 6691 women aged 65 years and older enrolled in the Study of Osteoporotic Fractures. Calcaneal BMD was measured at an initial exam and after an average of 5.9 years of follow-up. Hip BMD was measured at an initial exam and after 3.7 years of follow-up. Baseline spine BMD and hip structural parameters were measured. Incident hip fractures were confirmed by review of radiographic reports; follow-up was greater than 98% complete. Incident vertebral fractures were defined by morphometry using lateral spine radiography at baseline and an average of 3.7 years later. The frequencies of the NOS3 Glu298Asp genotypes were Glu/Glu=46.2%, Glu/Asp=42.7%, and Asp/Asp=11.1%. There were no significant associations between NOS3 genotypes and initial calcaneal BMD, hip BMD, or rate of change in hip or calcaneal BMD. None of the hip structural parameters differed substantially by genotype. NOS3 genotype was not significantly associated with either incident or prevalent radiographic vertebral fractures. Women with the heterozygous Glu/Asp genotype had a bord...Continue Reading

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Citations

Sep 13, 2008·Calcified Tissue International·Gregory J TranahUNKNOWN Study of Osteoporotic Fractures (SOF) Research Group
May 25, 2007·Current Osteoporosis Reports·Thomas J Beck
Jun 13, 2009·Maturitas·Sibel Cubukcu FiratSibel Berker Karauzum
Sep 23, 2008·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Ashraf F Nabhan, Noha H Rabie
Apr 15, 2015·Menopause : the Journal of the North American Menopause Society·Eun Hee ChunJung Gu Kim
Sep 24, 2015·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Gina M Policastro, Matthew L Becker
Aug 4, 2009·Journal of Zhejiang University. Science. B·Shun-zhi LiuShe-min Lu
Jun 29, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P SzulcP D Delmas
Jan 5, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K Uusi-RasiK D Harper
Mar 1, 2008·Expert Review of Endocrinology & Metabolism·Yan GuoHong-Wen Deng

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