PMID: 8947930Nov 1, 1996Paper

Association of enkephalin catabolism inhibitors and CCK-B antagonists: a potential use in the management of pain and opioid addiction

Neurochemical Research
B P Roques, F Noble

Abstract

The overlapping distribution of opioid and cholecystokinin (CCK) peptides and their receptors (mu and delta opioid receptors; CCK-A and CCK-B receptors) in the central nervous system have led to a large number of studies aimed at clarifying the functional relationships between these two neuropeptides. Most of the pharmacological studies devoted to the role of CCK and enkephalins have been focused on the control of pain. Recently the existence of regulatory mechanisms between both systems have been proposed, and the physiological antagonism between CCK and endogenous opioid systems has been definitely demonstrated by coadministration of CCK-B selective antagonists with RB 101, a systemically active inhibitor, which fully protects enkephalins from their degradation. Several studies have also been done to investigate the functional relationships between both systems in development of opioid side-effects and in behavioral responses. This article will review the experimental pharmacology of association of enkephalin-degrading enzyme inhibitors and CCK-B antagonists to demonstrate the interest of these molecules in the management of both pain and opioid addiction.

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Citations

May 23, 2001·Psychiatry Research·J VanakoskiD Goldman
Jan 1, 1997·Peptides·G A OlsonA J Kastin
Jun 15, 1999·Progress in Neurobiology·F Noble, B P Roques
Mar 22, 2008·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Shahid Husain, David E Potter
Feb 2, 2008·Bulletin of Experimental Biology and Medicine·L G KolikS B Seredenin
May 20, 2015·British Journal of Pharmacology·Florence NobleNicolas Marie
Dec 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joanna Starnowska-Sokół, Barbara Przewłocka
Oct 6, 2000·Journal of Medicinal Chemistry·M Martín-MartínezR González-Muñiz
Jun 6, 2006·Cellular Signalling·Nicolas MarieStéphane Allouche

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