Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case-control study

BMC Public Health
F BalazardAnne Gourdin Et Catherine Dumont

Abstract

The incidence of childhood type 1 diabetes (T1D) incidence is rising in many countries, supposedly because of changing environmental factors, which are yet largely unknown. The purpose of the study was to unravel environmental markers associated with T1D. Cases were children with T1D from the French Isis-Diab cohort. Controls were schoolmates or friends of the patients. Parents were asked to fill a 845-item questionnaire investigating the child's environment before diagnosis. The analysis took into account the matching between cases and controls. A second analysis used propensity score methods. We found a negative association of several lifestyle variables, gastroenteritis episodes, dental hygiene, hazelnut cocoa spread consumption, wasp and bee stings with T1D, consumption of vegetables from a farm and death of a pet by old age. The found statistical association of new environmental markers with T1D calls for replication in other cohorts and investigation of new environmental areas. Clinical-Trial.gov NCT02212522 . Registered August 6, 2014.

References

May 4, 2018·PloS One·Mathilde LouvigneRegis Coutant

Citations

May 29, 2002·Diabetologia·E A M Gale
Sep 20, 2002·The New England Journal of Medicine·Jean-Francois Bach
Mar 27, 2004·Lancet·E A M GaleEuropean Nicotinamide Diabetes Intervention Trial (ENDIT) Group
May 25, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·J GreenR Newton
Aug 5, 2004·The Journal of Clinical Endocrinology and Metabolism·Jennifer M BarkerDiabetes Autoimmunity Study in the Young
Aug 17, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·DIAMOND Project Group
Nov 30, 2006·Annals of the New York Academy of Sciences·William A HagopianBeena Akolkar
Sep 27, 2007·JAMA : the Journal of the American Medical Association·J M NorrisMarian Rewers
Jan 14, 2009·Pharmacology, Biochemistry, and Behavior·Anurag KuhadKanwaljit Chopra
Apr 14, 2009·American Journal of Epidemiology·Thomas HarderAndreas Plagemann
May 28, 2010·PloS One·Chirag J PatelAtul J Butte
Aug 4, 2010·Archives of Pediatrics & Adolescent Medicine·Marisa A D'AngeliBeth A Mueller
Dec 21, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·K C VerbeetenK K Ong
Aug 17, 2011·Current Opinion in Endocrinology, Diabetes, and Obesity·Gregory P Forlenza, Marian Rewers
Jul 5, 2012·Cold Spring Harbor Perspectives in Medicine·Mikael Knip, Olli Simell
Sep 22, 2012·Islets·Nora M ChapmanSteven Tracy
Dec 13, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·Jay S Skyler
Jun 5, 2013·Journal of Molecular Endocrinology·Francesco Maria Egro
Dec 10, 2013·Nucleic Acids Research·Danielle WelterHelen Parkinson
Mar 25, 2014·Environmental Health Perspectives·Stephen M RappaportAugustin Scalbert
Jun 11, 2014·JAMA : the Journal of the American Medical Association·Mikael KnipTRIGR Study Group
Jul 22, 2014·Pediatric Diabetes·H Peter ChaseType 1 Diabetes TrialNet Nutritional Intervention to Prevent (NIP) Type 1 Diabetes Study Group
Jul 31, 2014·Diabetologia·Darius A Schneider, Matthias G von Herrath
Nov 5, 2014·Nature·Kyle Kai-How FarhBradley E Bernstein
Aug 26, 2015·Proceedings of the National Academy of Sciences of the United States of America·Changyun HuLi Wen
Dec 3, 2015·Journal of Lipid Research·Yongeun KimSoonkyu Chung
Apr 28, 2016·Nature Genetics·John Stamatoyannopoulos

Related Concepts

Biological Markers
Genome-Wide Association Study
Study
Area
WAS gene
Cacao Plant
Ergocalciferol
Hazelnut allergenic extract
NCS1 gene
Environment

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Related Papers

The Journal of the Singapore Paediatric Society
W H Boon
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
E SøreideS Harboe
The Practitioner
T K MARSHALL
The Practitioner
C A Birch
© 2020 Meta ULC. All rights reserved