Association of EPCR Polymorphism rs867186-GG With Severity of Human Malaria

Frontiers in Genetics
Juan Carlos CespedesMingli Liu

Abstract

Cerebral malaria (CM) is characterized by the sequestration of Plasmodium-infected erythrocytes (pRBCs) to host brain microvasculature beds via P. falciparum erythrocyte membrane protein 1 (PfEMP1). Under normal conditions, activated protein C (APC) bound to endothelial protein C receptor (EPCR) has cytoprotective properties via the activation of protease-activated receptor 1 (PAR1). During malaria infection, pRBCs transports PfEMP1 to the membranes to bind EPCR in the same region as APC. As a result, APC is less capable of inducing cytoprotective effects via PAR1. Two studies involving adult malaria patients revealed that EPCR rs867186-GG allele is associated with protection against severe malaria, while three other studies involving child malaria patients could not show association between EPCR rs867186-GG genotype and severe malaria or increased mortality among children with CM. We examined the association between the EPCR rs867186-GG genotype and the protection against cerebral malaria. Peripheral blood samples were collected from 47 malaria patients and 34 healthy individuals from a study conducted from 2004 to 2007 at the NSCB Medical College Hospital in India. CM and malaria-associated complications were defined based on...Continue Reading

References

Nov 5, 1997·The American Journal of Tropical Medicine and Hygiene·C NewboldK Marsh
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Morten A NielsenLars Hviid
Jan 15, 2004·The Journal of Infectious Diseases·Samuel Crocodile WassmerGeorges Emile Grau
Sep 13, 2008·Annual Review of Microbiology·Artur ScherfLoïc Riviere
Oct 9, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Rashid DeaneBerislav V Zlokovic
Aug 14, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gerald K K ChamThor G Theander
Jun 1, 2011·British Journal of Haematology·Christopher A MoxonAlister G Craig
May 24, 2012·Proceedings of the National Academy of Sciences of the United States of America·Thomas LavstsenThor G Theander
Dec 5, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anja BengtssonAnja T R Jensen
Oct 9, 2013·Thrombosis Research·Pantep Angchaisuksiri
Jul 23, 2014·Blood·L Vijaya Mohan RaoUsha R Pendurthi
Mar 19, 2015·The New England Journal of Medicine·Karl B SeydelTerrie E Taylor
May 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Maria BernabeuJoseph D Smith
May 22, 2016·Thrombosis Research·Laurent O Mosnier, Thomas Lavstsen
Jun 30, 2016·EMBO Molecular Medicine·Jakob S JespersenThomas Lavstsen
Dec 13, 2016·Trends in Parasitology·Maria Bernabeu, Joseph D Smith
Sep 3, 2017·The Journal of Infectious Diseases·Nicaise Tuikue NdamPhilippe Deloron
Feb 21, 2018·Current Opinion in Hematology·Usha R Pendurthi, L Vijaya Mohan Rao

❮ Previous
Next ❯

Methods Mentioned

BETA
SMA
PCR

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.