Association of epicardial and abdominal visceral adipose tissue with coronary atherosclerosis in patients with a coronary artery calcium score of zero

Circulation Journal : Official Journal of the Japanese Circulation Society
Hiroshi TsushimaYasuki Kihara

Abstract

We sought to examine whether epicardial and abdominal visceral adipose tissue distribution is associated with coronary atherosclerosis in patients with a coronary artery calcium (CAC) score of zero, assessed by coronary computed tomography angiography (CCTA). We studied 352 patients with suspected coronary artery disease (mean age 61±11 years, 57% male) with a CAC score of zero who had undergone CCTA. Non-calcified coronary plaques (NCPs) were detected in 102 patients (29%); those causing ≥50% stenosis were found in 15 patients (4%). Patients were divided into 4 groups on the basis of CT-based epicardial adipose tissue (EAT) volume and abdominal visceral adipose tissue (VAT) area using the sex-specific median value. Multivariate analysis showed that the adjusted odds ratios for the presence of NCPs in the high VAT area/low EAT volume group, and the high VAT area/high EAT volume group were 2.80 (95% confidence interval [95% CI]: 1.25-6.35, P=0.01) and 2.68 (95% CI: 1.36-5.45, P=0.004), respectively. Interestingly, the low VAT area/high EAT volume group showed an equivalent adjusted odds ratio of 3.02 (95% CI: 1.33-6.90, P=0.008). EAT volume is eligible as a marker to be evaluated in addition to VAT area in patients with a CAC sc...Continue Reading

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Citations

Dec 15, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Atsushi Nohara
Apr 14, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Sadako MotoyamaYukio Ozaki
Apr 8, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Hideya Yamamoto, Yasuki Kihara
Jul 20, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Ichiro Kishimoto
Sep 2, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Noriyuki OuchiToyoaki Murohara
Oct 14, 2016·Journal of Atherosclerosis and Thrombosis·Koichi Kaikita
Sep 7, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Yukina HirataMasataka Sata
Mar 6, 2019·Journal of Clinical Medicine·Narothama Reddy AeddulaSamata Pathireddy
Mar 25, 2019·Cardiovascular Research·Rosalinda MadonnaRaffaele De Caterina
Jul 12, 2019·Pediatric Diabetes·Melissa A ChambersMicah L Olson
Jun 13, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Wayne Bond LauNoriyuki Ouchi
Mar 13, 2019·European Radiology·Yasunori NagayamaYasuyuki Yamashita
Sep 29, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Fumi SatoIichiro Shimomura
Jun 21, 2017·Atherosclerosis·Dimitry A ChistiakovAlexander N Orekhov
Feb 16, 2021·Arthritis & Rheumatology·George A KarpouzasMatthew J Budoff

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