Association of Epigenetic Clock with Consensus Molecular Subtypes and Overall Survival of Colorectal Cancer

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Chunlei ZhengRong Xu

Abstract

Epigenetic clock, or DNA methylation age, has been shown to highly correlate with chronologic age. Epigenetic age acceleration, the difference between DNA methylation age and individual's chronologic age, was observed in colorectal cancer. However, the association of epigenetic age acceleration with colorectal cancer tumor molecular characteristics, clinical characteristics, and patient outcomes has not been systematically investigated. DNA methylation ages of 345 patients with colorectal cancer from The Cancer Genome Atlas (TCGA) were computed using the Horvath age prediction model. Multivariate linear regression was used to assess the association of epigenetic age acceleration with molecular and clinical features of colorectal cancer, including consensus molecular subtypes (CMS1-CMS4) and tumor stage Cox proportional hazards regression was used to assess the association of epigenetic age acceleration with survival. Epigenetic age acceleration is significantly associated with CMS. Compared with CMS2, epigenetic age acceleration for CMS1, CMS3, and CMS4 was 23.90 years [P = 5.55E-11; 95% confidence interval (CI): 17.10-30.69], 9.16 years (P = 5.84E-03; 95% CI: 2.68-15.65), and 6.05 years (P = 2.69E-02; 95% CI: 0.70-11.41), resp...Continue Reading

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Citations

Jan 5, 2020·Clinical Epigenetics·Ting WangWilliam M Grady
Jul 22, 2020·PloS One·Chunlei ZhengRong Xu
Dec 24, 2019·Frontiers in Bioengineering and Biotechnology·Tongtong ZhuShangwei Ning
Nov 12, 2020·Experimental Biology and Medicine·Xi HeJingshan Shi
Jan 5, 2021·International Journal of Cancer. Journal International Du Cancer·Chung-Ho E Lau, Oliver Robinson
Jan 1, 2021·International Journal of Molecular Sciences·Andrea MaugeriGuido Basile
Feb 26, 2021·Aging·Priscila ChiavelliniRodolfo G Goya

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