PMID: 11913680Mar 27, 2002Paper

Association of Epstein-Barr virus and nasopharyngeal carcinoma in Caucasian patients

The Annals of Otology, Rhinology, and Laryngology
Guillermo PlazaCarmen Bellas

Abstract

We evaluated the association of nasopharyngeal carcinoma (NPC) and Epstein-Barr virus (EBV) in Spanish patients, and studied the expression of EBV products (latent membrane protein-1 [LMP-1] and ZEBRA proteins) by NPC cells and its possible prognostic value. In situ hybridization (ISH) for EBV-encoded nonpolyadenylated RNAs (EBERs) and immunohistochemical expression of LMP-1 and ZEBRA proteins by immunohistochemistry were examined in formalin-fixed, paraffin-embedded NPC specimens from 30 patients, and a survival analysis was done by the Kaplan-Meier method. We detected EBERs by ISH in 96.67% of the NPC cases, and detected expression of LMP-I in 43.33% of the NPC cases and expression of ZEBRA protein in 6.67% of the NPC cases. We conclude that ISH for expression of EBERs is an adequate method for detection of EBV in NPC. LMP-1 is not frequently expressed in NPC cells (43.33%). Most NPC cells carry a latent EBV infection. LMP-1 expression might have worsened the prognosis of NPC in our series.

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Citations

Jun 1, 2014·Archives of Pathology & Laboratory Medicine·Akeesha A ShahEdward B Stelow
Feb 21, 2004·American Journal of Otolaryngology·Neil Bhattacharyya
Oct 3, 2008·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Carla d'Espiney AmaroJoão Olias
Nov 18, 2003·Clinical Otolaryngology and Allied Sciences·A Robson
Feb 27, 2008·Virchows Archiv : an International Journal of Pathology·Yeşim ErtanSaliha Soydan
Nov 18, 2010·Expert Review of Anticancer Therapy·Manas SharmaEugene Yu
Sep 19, 2021·The FEBS Journal·Kwun Wah WenBlossom Damania

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