Association of ERBB4 genetic polymorphism with the risk and prognosis of non-small cell lung cancer in Chinese Han population: A population-based case-control study.

Medicine
Wan-Ping WangDing Wei

Abstract

The aim of this study was to explore the association of rs1836724 single-nucleotide polymorphism (SNP) of ERBB4 with risk and prognosis of non-small cell lung cancer (NSCLC) in the Chinese Han population.The genotype of rs1836724 SNP of ERBB4 from 258 patients with NSCLC and 200 noncancer controls were detected the TaqMan-MGB probes real-time fluorescence polymerase chain reaction. The distribution of genotype and alleles between the 2 groups was compared, and the association between clinicopathological characteristic and rs1836724 SNP was analyzed. Prognosis and influencing factors were analyzed by Kaplan-Meier and Cox regression analysis.There were significant differences in the genotype and allele distribution of ERBB4 rs1836724 between the NSCLC group and control group (P < .05). And CC genotype of rs1836724 was associated with increased risk of NSCLC in the Chinese Han population. Rs1836724 SNP was associated with TNM stage and lymph nodal metastasis (P = .001, P = .007). The median follow-up was 29 months, and the progression-free survival and overall survival of 258 NSCLC patients were 27.91% and 31.39%, respectively. Patients with GG genotype of rs1836724 had poor progression-free survival and overall survival. Rs183672...Continue Reading

References

Feb 8, 2006·International Journal of Cancer. Journal International Du Cancer·Alex StarrRami Ben-Yosef
Dec 21, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matjaz RokavecHiltrud Brauch
Feb 2, 2012·World Journal of Gastroenterology : WJG·Qiang YuJin-Kun Zhang
Sep 11, 2013·Proceedings of the National Academy of Sciences of the United States of America·Monica Red BrewerWilliam Pao
Jun 6, 2014·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Suzy DaviesBridget S Wilson
Oct 23, 2014·Cancer Biomarkers : Section a of Disease Markers·Xueren GaoZhansheng Zhu
Nov 14, 2014·The Journal of Biological Chemistry·Hongwei LiangXi Chen
Apr 29, 2015·Carcinogenesis·Christopher S WilliamsMark R Frey
Jun 9, 2015·Oncogene·K J KurppaK Elenius
Aug 9, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Mirza MasroorAlpana Saxena
Jun 5, 2016·Surgical Oncology Clinics of North America·Min Zheng
Oct 20, 2018·The Breast : Official Journal of the European Society of Mastology·Masoumeh Mansouri BidkaniKamran Ghaedi
Aug 6, 2019·Mayo Clinic Proceedings·Narjust DumaJulian R Molina
Mar 29, 2020·Cellular Oncology (Dordrecht)·Vincent F M SegersGilles W De Keulenaer

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