Association of estrogen receptor 1 intron 1 C/T polymorphism in Korean vitiligo patients

Journal of Dermatological Science
Sheng-Yu JinMu-Hyoung Lee

Abstract

Vitiligo is a common disease characterized by cutaneous white maculae due to loss of melanocytes. It is a polygenic disease, however, the exact pathogenesis of vitiligo is not yet known. The estrogen receptor (ESR) 1 gene was selected as a candidate gene because some researchers treated vitiligo successfully with the steroid-thyroid hormone mixture containing estrogen. Furthermore ESR was expressed in the melanocytes which have an important role in the pigmentation. The polymorphisms of ESR1 gene in vitiligo patients was not reported yet. To determine whether polymorphisms of ESR1 gene were associated with susceptibility to vitiligo patients in Korean population. We conducted case-control association study of vitiligo patients (120) and healthy controls (254). Genotypes of ESR1 gene (intron 1 C/T, exon 4 C/G, and exon 8 A/G) were determined by polymerase chain reaction followed by restriction enzyme digestion. Intron 1 T/C allele frequency was significantly different between patients and controls (P = 0.034). Intron 1 T/C genotype distribution (P = 0.021) and allele frequency (P = 0.013) were different between female vitiligo patients and female controls. Intron 1 T/C allele frequency showed significantly difference between gen...Continue Reading

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Citations

May 13, 2006·Archives of Dermatological Research·Ayca Cordan YaziciUmit Tursen
Jan 11, 2012·Nature Reviews. Rheumatology·Linda J Sandell
Aug 14, 2008·Current Opinion in Rheumatology·Steffan Daniël BosIngrid Meulenbelt
Feb 20, 2008·Photochemistry and Photobiology·Márta SzéllLajos Kemény
Nov 19, 2010·The Journal of Investigative Dermatology·Stanca A BirleaRichard A Spritz
Jun 15, 2007·The Journal of Investigative Dermatology·Yanhua LiangXuejun Zhang
Jul 3, 2009·The Journal of Investigative Dermatology·Ling LiuTianwen Gao
Jul 17, 2007·Pigment Cell Research·Richard A Spritz
Mar 16, 2017·Interdisciplinary Sciences, Computational Life Sciences·Anvita Gupta MalhotraKhushhali M Pandey

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