Association of extracerebral organ failure with 1-year survival and healthcare-associated costs after cardiac arrest: an observational database study

Critical Care : the Official Journal of the Critical Care Forum
Pirkka T PekkarinenM B Skrifvars

Abstract

Organ dysfunction is common after cardiac arrest and associated with worse short-term outcome, but its impact on long-term outcome and treatment costs is unknown. We used nationwide registry data from the intensive care units (ICU) of the five Finnish university hospitals to evaluate the association of 24-h extracerebral Sequential Organ Failure Assessment (24h-EC-SOFA) score with 1-year survival and healthcare-associated costs after cardiac arrest. We included adult cardiac arrest patients treated in the participating ICUs between January 1, 2003, and December 31, 2013. We acquired the confirmed date of death from the Finnish Population Register Centre database and gross 1-year healthcare-associated costs from the hospital billing records and the database of the Finnish Social Insurance Institution. A total of 5814 patients were included in the study, and 2401 were alive 1 year after cardiac arrest. Median (interquartile range (IQR)) 24h-EC-SOFA score was 6 (5-8) in 1-year survivors and 7 (5-10) in non-survivors. In multivariate regression analysis, adjusting for age and prior independency in self-care, the 24h-EC-SOFA score had an odds ratio (OR) of 1.16 (95% confidence interval (CI) 1.14-1.18) per point for 1-year mortality....Continue Reading

References

Mar 1, 1975·Lancet·B Jennett, M Bond
Oct 12, 2001·JAMA : the Journal of the American Medical Association·F L FerreiraJ L Vincent
Jul 31, 2002·Circulation·Christophe AdrieJean-Marc Cavaillon
Jul 10, 2003·Intensive Care Medicine·Francisca García LizanaJean-Louis Vincent
Feb 28, 2004·Resuscitation·Anne-Cathrine Naess, Petter Andreas Steen
Sep 24, 2004·Circulation·Anouk P van AlemRudolph W Koster
Jul 22, 2008·Critical Care : the Official Journal of the Critical Care Forum·Jürgen GrafUwe Janssens
Dec 19, 2008·Critical Care : the Official Journal of the Critical Care Forum·Lilian MinneEvert de Jonge
Nov 19, 2011·Acta Anaesthesiologica Scandinavica·M ReinikainenUNKNOWN Finnish Intensive Care Consortium
Mar 6, 2012·Acta Anaesthesiologica Scandinavica·M ReinikainenUNKNOWN Finnish Intensive Care Consortium
Nov 20, 2012·Critical Care : the Official Journal of the Critical Care Forum·Yasser SakrUNKNOWN SOAP Investigators
Mar 20, 2013·Critical Care Medicine·Brian W RobertsStephen Trzeciak
Oct 20, 2015·Resuscitation·Koenraad G MonsieursUNKNOWN ERC Guidelines 2015 Writing Group
Mar 12, 2016·Resuscitation·Martin CourLaurent Argaud
Nov 15, 2016·Critical Care : the Official Journal of the Critical Care Forum·Leda NobileUNKNOWN ICON Investigators
Feb 25, 2017·Critical Care : the Official Journal of the Critical Care Forum·Harm-Jan de GroothHeleen M Oudemans-van Straaten
Aug 14, 2018·Resuscitation·Dylan E Stanger, Christopher B Fordyce

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