Abstract
The association between extraintestinal manifestations (EIMs) and disease activity suggest a common pathogenetic link with inflammatory bowel disease (IBD). We report on the association of EIMs and anaemia with long-term disease outcomes, including treatment steps, hospitalization, and surgery in the prospective population-based IBD inception cohort from Veszprem province. Data of 678 incident IBD patients (Crohn's disease/ulcerative colitis(CD/UC): 331/347) diagnosed from 1st January 2000 to 31st December 2012 were analyzed (CD: m/f: 176/155, median age at diagnosis: 28, IQR: 21-40 years, disease duration: 6, IQR: 2-9 years; UC: m/f: 200/147, median age at diagnosis: 36, IQR: 26-50 years, duration: 7, IQR: 4-10 years). EIMs were present in 30% of the CD and 17.3% of the UC patients. In CD, female gender (p = 0.02) need for steroid (p < 0.001) and azathioprine (AZA) (p = 0.02), while in UC, young age at onset (p = 0.03), extensive disease (p = 0.003), female gender (p = 0.07), need for steroids (p < 0.001) and AZA (p = 0.004) and need for IBD-related hospitalization (p = 0.01) were associated with the presence of EIMs. Anaemia was present in 56.7% of the CD and 30.2% of the UC patients. In both CD and UC anaemia was associated...Continue Reading
References
Sep 1, 1976·Medicine·A J GreensteinD B Sachar
Jan 1, 1989·Scandinavian Journal of Gastroenterology. Supplement·J E Lennard-Jones
Jul 1, 1996·Journal of Clinical Gastroenterology·F T VelosoF Magro
Nov 14, 1997·European Journal of Gastroenterology & Hepatology·C B Lamers
Apr 24, 2001·The American Journal of Gastroenterology·C N BernsteinN Yu
Oct 11, 2002·Scandinavian Journal of Gastroenterology·T LjungP M Hellström
Oct 17, 2003·World Journal of Gastroenterology : WJG·Laszlo LakatosPeter Laszlo Lakatos
May 16, 2006·Gut·J SatsangiJ-F Colombel
Sep 3, 2010·The American Journal of Gastroenterology·Stephan R VavrickaAlain M Schoepfer
Dec 3, 2010·Journal of Crohn's & Colitis·Manuela VoegtlinUNKNOWN Swiss IBD Cohort Study
Nov 11, 2011·Inflammatory Bowel Diseases·Laszlo LakatosPeter Laszlo Lakatos
Jan 12, 2012·The American Journal of Gastroenterology·Peter Laszlo LakatosLaszlo Lakatos
Nov 1, 2013·Alimentary Pharmacology & Therapeutics·M L HøivikUNKNOWN IBSEN study group
Feb 28, 2014·Inflammatory Bowel Diseases·Natalie FilmannIrina Blumenstein
Oct 1, 2014·Inflammatory Bowel Diseases·Daniel SjöbergAnders Rönnblom
Dec 24, 2014·Scandinavian Journal of Gastroenterology·Rune IseneUNKNOWN EC-IBD Study Group
Apr 12, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ioannis E KoutroubakisDavid G Binion
May 29, 2015·Inflammatory Bowel Diseases·Stephan R VavrickaAlain M Schoepfer
Citations
Jun 22, 2016·Scientific Reports·Chia-Chun TsengJeng-Hsien Yen
Oct 6, 2017·Journal of Crohn's & Colitis·Dana DuricovaUNKNOWN EPIMAD Group
Aug 8, 2018·Inflammatory Bowel Diseases·Dana DuricovaUNKNOWN Epimad Group
Nov 18, 2018·Journal of Crohn's & Colitis·C R H HedinF Rieder
Mar 12, 2019·Journal of Crohn's & Colitis·Roy FreiLuc Biedermann
May 23, 2020·Journal of Clinical Medicine·Ferdinando D'AmicoSilvio Danese
Sep 10, 2020·Nature Reviews. Gastroenterology & Hepatology·Wendy A GoodmanTheresa T Pizarro
Dec 10, 2019·Gut and Liver·Weimin XuPeng Du
Mar 23, 2017·Alimentary Pharmacology & Therapeutics·Z VeghP L Lakatos
Feb 22, 2018·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Francesc Casellas JordáJavier Júdez Gutiérrez
Jul 16, 2019·PeerJ·Weimin XuPeng Du
Jul 3, 2020·Scientific Reports·M J GarcíaM Rivero
Apr 19, 2018·Inflammatory Bowel Diseases·Matiar MadanchiUNKNOWN Swiss IBD Cohort Study Group
Aug 10, 2019·European Journal of Clinical Nutrition·Shlomi CohenAnat Yerushalmy-Feler
Mar 19, 2020·Journal of Pediatric Gastroenterology and Nutrition·Sabine JanssonVibeke Wewer
Jul 11, 2018·Digestive Diseases and Sciences·Ji Young ChangWon-Ho Kim
Oct 31, 2019·United European Gastroenterology Journal·David Marti-AguadoMiguel Minguez
Nov 18, 2020·Nutrients·Aditi Kumar, Matthew J Brookes
Jan 2, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Alfredo J LucendoÁngel Arias
Jul 1, 2021·BMC Gastroenterology·Kalliopi FoteinogiannopoulouUNKNOWN Hellenic group for the study of IBD