Association of extraintestinal manifestations and anaemia with disease outcomes in patients with inflammatory bowel disease

Scandinavian Journal of Gastroenterology
Zsuzsanna VeghPeter Laszlo Lakatos

Abstract

The association between extraintestinal manifestations (EIMs) and disease activity suggest a common pathogenetic link with inflammatory bowel disease (IBD). We report on the association of EIMs and anaemia with long-term disease outcomes, including treatment steps, hospitalization, and surgery in the prospective population-based IBD inception cohort from Veszprem province. Data of 678 incident IBD patients (Crohn's disease/ulcerative colitis(CD/UC): 331/347) diagnosed from 1st January 2000 to 31st December 2012 were analyzed (CD: m/f: 176/155, median age at diagnosis: 28, IQR: 21-40 years, disease duration: 6, IQR: 2-9 years; UC: m/f: 200/147, median age at diagnosis: 36, IQR: 26-50 years, duration: 7, IQR: 4-10 years). EIMs were present in 30% of the CD and 17.3% of the UC patients. In CD, female gender (p = 0.02) need for steroid (p  < 0.001) and azathioprine (AZA) (p = 0.02), while in UC, young age at onset (p = 0.03), extensive disease (p = 0.003), female gender (p = 0.07), need for steroids (p < 0.001) and AZA (p = 0.004) and need for IBD-related hospitalization (p = 0.01) were associated with the presence of EIMs. Anaemia was present in 56.7% of the CD and 30.2% of the UC patients. In both CD and UC anaemia was associated...Continue Reading

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Citations

May 23, 2020·Journal of Clinical Medicine·Ferdinando D'AmicoSilvio Danese
Sep 10, 2020·Nature Reviews. Gastroenterology & Hepatology·Wendy A GoodmanTheresa T Pizarro
Feb 22, 2018·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Francesc Casellas JordáJavier Júdez Gutiérrez
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Aug 10, 2019·European Journal of Clinical Nutrition·Shlomi CohenAnat Yerushalmy-Feler
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Jan 2, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Alfredo J LucendoÁngel Arias
Jul 1, 2021·BMC Gastroenterology·Kalliopi FoteinogiannopoulouUNKNOWN Hellenic group for the study of IBD

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Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.