Association of Fcgamma receptor IIB gene polymorphism with genetic susceptibility to systemic lupus erythematosus in Chinese populations--a family-based association study

Journal of Dermatological Science
F PanD Ye

Abstract

The aim of this study was to investigate the role of FcgammaRIIB gene in susceptibility to systemic lupus erythematosus (SLE) using family-based association analysis method, and to examine possible haplotypes between two single-nucleotide polymorphisms. A total of 119 patients with SLE from 95 nuclear families, aged from 14 to 78 years, was selected according to 1997 criteria of American College of Rheumatology (ACR), In addition, 316 family members of these patients were also genotyped. A family-based association study was used to explore the relationship between gene polymorphism and SLE. We studied two single-nucleotide polymorphisms (SNPs) encoding non-synonymous substitution in the FcgammaRIIB gene with respect to genetic susceptibility to SLE. The FcgammaRIIB gene was genotyped by restriction fragment length polymorphism (RFLP) method. Among 119 SLE patients, the frequencies of FcgammaRIIB-C50T CC, CT and TT genotypes were 12.7%, 60.7% and 26.6%, respectively. The frequencies of FcgammaRIIB-T225C TT, TC and CC genotypes were 8.1%, 61.3% and 30.6%, respectively. Four haplotypes, 50T-225C (34.1%), 50C-225C (27.7%), 50T-225T (19.7%) and 50C-50T (18.5%) were reconstructed. Univariate (single-marker) family-based association t...Continue Reading

References

Jun 29, 2001·Trends in Immunology·J G TewD Qin
Sep 2, 2003·Nature Reviews. Immunology·Marie H Kosco-Vilbois
Jul 24, 2007·Indian Journal of Dermatology, Venereology and Leprology·S Amladi

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Citations

Oct 19, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·L JakabB Fekete
Mar 3, 2018·Protein & Cell·Junyi WangWanli Liu
Nov 14, 2008·Autoimmunity·Valerio NapolioniFranco Maria Venanzi
May 3, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Liling XuWanli Liu
Dec 11, 2019·Antibodies·Veena A Thomas, Joseph P Balthasar

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