Association of FCRL3 Genetic Polymorphisms With Endometriosis-Related Infertility Risk: An Independent Study in Han Chinese

Medicine
Haiyan ZhangBeibei Xie

Abstract

The Fc receptor-like 3 (FCRL3) gene was reported to be linked to a variety of autoimmune diseases, including endometriosis-related infertility. However, this linkage has not been studied in Chinese population and there has been no meta-analysis on the interrelationship of FCRL3 gene and endometriosis-related infertility. The aim of the study was to investigate the association between FCRL3 genetic polymorphisms and the risk of endometriosis-related infertility in Han Chinese, and a further meta-analysis was conducted to confirm our results.Four single nucleotide polymorphisms (SNPs) (rs7528684 [FCRL3_3], rs11264799 [FCRL3_4], rs945635 [FCRL3_5], and rs3761959 [FCRL3_6]) on FCRL3 gene were genotyped in a case-control cohort composed of 217 patients suffering from endometriosis-related infertility and 220 healthy controls using cleaved amplification polymorphism sequence-tagged sites (polymerase chain reaction-restriction fragment length polymorphism, PCR-RFLP). Odds ratio (OR) and its 95% confidence interval (CI) was used to evaluate the association quantitatively. Furthermore, a meta-analysis of previous studies including the present study was implemented through Stata 11.0 (Stata Corporation, College Station, TX).We found an a...Continue Reading

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Citations

Aug 18, 2018·Experimental and Therapeutic Medicine·Loukia VassilopoulouGeorge N Goulielmos
Apr 17, 2019·Experimental and Therapeutic Medicine·Loukia VassilopoulouGeorge N Goulielmos
Apr 14, 2017·Journal of Assisted Reproduction and Genetics·Maciej OsińskiMalgorzata Szczepańska
Nov 7, 2020·International Journal of Molecular Sciences·Beata SmolarzHanna Romanowicz
Apr 8, 2021·Archives of Gynecology and Obstetrics·Beata Smolarz, Hanna Romanowicz
Aug 28, 2021·International Journal of Molecular Sciences·Elisa GiacominiPaola Viganò

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Methods Mentioned

BETA
Assay
PCR

Software Mentioned

Assay Design
Stata

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