Association of FcRn expression with lung abnormalities and IVIG catabolism in patients with common variable immunodeficiency

Clinical Immunology : the Official Journal of the Clinical Immunology Society
T FreibergerJ Litzman

Abstract

The neonatal Fc receptor (FcRn) acts as a key regulator of IgG homeostasis and is an important sensor of luminal infection. We analyzed the influence of FcRn expression on disease phenotype and the catabolism of therapeutically administered intravenous immunoglobulins (IVIG) in 28 patients with common variable immunodeficiency (CVID). Patients with generalized bronchiectasis and fibrosis had lower levels of FCRN mRNA compared to patients without these complications (P=0.027 and P=0.041, respectively). Moreover, FCRN mRNA levels correlated negatively with the extent of bronchiectasis and the rate of IgG decline after infusion of IVIG (P=0.027 and P=0.045, respectively). No relationship of FCRN expression with age at disease onset, age at diagnosis, diagnostic delay, IgG levels or frequency of infections before or during replacement immunoglobulin treatment, the presence of lung functional abnormalities, chronic diarrhea, granulomas, lymphadenopathy, splenomegaly or autoimmune phenomena was observed. Our results showed that FcRn might play a role in the development of lung structural abnormalities and in the catabolism of IVIG in patients with CVID.

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Citations

Feb 4, 2016·Pediatrics International : Official Journal of the Japan Pediatric Society·Susumu YamazakiToshiaki Shimizu
Feb 26, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Stephen Jolles
Aug 8, 2015·The Journal of Allergy and Clinical Immunology. in Practice·Mary LucasHelen Chapel
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Jun 12, 2013·MAbs·Christophe PassotValérie Gouilleux-Gruart
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Mar 7, 2017·Clinical and Experimental Immunology·J P Hodkinson
Aug 9, 2017·Immunogenetics·Zhanna ShubinBhawna Poonia
Jan 6, 2018·Pharmaceutical Research·Daniel C Ferguson, Javier G Blanco
Apr 17, 2020·Frontiers in Immunology·Luke A WallRicardo U Sorensen
Dec 11, 2020·Cancer Control : Journal of the Moffitt Cancer Center·Hiroki HataYoshitaka Yano
Dec 31, 2020·British Journal of Clinical Pharmacology·Jian Lynn LeeNoraida Mohamed Shah
May 8, 2021·International Immunopharmacology·Jian Lynn LeeShamin Mohd Saffian

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