Association of first-line and second-line antiretroviral therapy adherence

Open Forum Infectious Diseases
Habib O RamadhaniWilliam C Miller

Abstract

Adherence to first-line antiretroviral therapy (ART) may be an important indicator of adherence to second-line ART. Evaluating this relationship may be critical to identify patients at high risk for second-line failure, thereby exhausting their treatment options, and to intervene and improve patient outcomes. Adolescents and adults (n = 436) receiving second-line ART were administered standardized questionnaires that captured demographic characteristics and assessed adherence. Optimal and suboptimal cumulative adherence were defined as percentage adherence of ≥90% and <90%, respectively. Bivariable and multivariable binomial regression models were used to assess the prevalence of suboptimal adherence percentage by preswitch adherence status. A total of 134 of 436 (30.7%) participants reported suboptimal adherence to second-line ART. Among 322 participants who had suboptimal adherence to first-line ART, 117 (36.3%) had suboptimal adherence to second-line ART compared with 17 of 114 (14.9%) who had optimal adherence to first-line ART. Participants who had suboptimal adherence to first-line ART were more likely to have suboptimal adherence to second-line ART (adjusted prevalence ratio, 2.4; 95% confidence interval, 1.5-3.9). Adher...Continue Reading

References

Dec 21, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Christian LaurentUNKNOWN ANRS 1215/1290 Study Group
Jun 29, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Louise C IversKaren Doucette
Nov 4, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stephen D LawnRobin Wood
Aug 31, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David R Bangsberg
Nov 30, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Karina M Berg, Julia H Arnsten
Nov 9, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Habib O RamadhaniJohn A Crump
May 16, 2008·The New England Journal of Medicine·Sharon A RiddlerUNKNOWN AIDS Clinical Trials Group Study A5142 Team
Apr 30, 2009·AIDS Research and Therapy·Mary B CauldbeckKadappa Shivappa Satish
Oct 20, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Matthew P FoxIan Sanne
Mar 10, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jean-Jacques ParientiUNKNOWN ESPOIR and REACH study groups
Apr 17, 2010·AIDS·Richard A MurphyUNKNOWN South Africa Resistance Cohort Study Team
Jul 20, 2010·JAMA : the Journal of the American Medical Association·Mar Pujades-RodríguezUNKNOWN AIDS Working Group of MSF
Jan 18, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Gert Uves van ZylGary Maartens
Mar 4, 2011·Journal of the International Association of Physicians in AIDS Care : JIAPAC·May Myat WinSomnuek Sungkanuparph
Mar 27, 2012·The Journal of Infectious Diseases·Kim C E SigaloffUNKNOWN PharmAccess African Studies to Evaluate Resistance (PASER)
Jun 14, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Richard A MurphyJean B Nachega
Dec 20, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Molly F FrankeMichael L Rich
Nov 15, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Ira B WilsonUNKNOWN Multisite Adherence Collaboration on HIV 14 Investigators

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Citations

Jun 30, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Wasana PrasitsuebsaiAnnette H Sohn
Jul 16, 2016·BMC Health Services Research·Habib O RamadhaniJohn A Bartlett
Apr 16, 2019·Journal of the International AIDS Society·John M HumphreyKara Wools-Kaloustian
Oct 24, 2019·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Samuel Essien-BaidooJustice Afrifa
Feb 12, 2017·AIDS and Behavior·Habib O RamadhaniJohn A Bartlett

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

SAS

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