Association of florfenicol residues with the abundance of oxazolidinone resistance genes in livestock manures

Journal of Hazardous Materials
Yingyu WangXi Xia

Abstract

Livestock and poultry manures are major reservoirs of antibiotic-resistant bacteria and antibiotic resistance genes (ARGs). Linezolid is a clinical medicine for humans and has never been approved for use in livestock. Interestingly, three linezolid resistance genes (cfr, optrA, and poxtA) have been detected in bacteria of animal origin, arousing public concern. This study investigated the abundance of three ARGs, cfr, optrA, and poxtA, in manures from 157 large-scale farms in China using real-time quantitative polymerase chain reaction. The residual concentrations of linezolid, florfenicol, tiamulin, and valnemulin were determined using ultra-high performance liquid chromatography-tandem mass spectrometry. A total of 140 livestock farms were tested positive for ARGs, and the positive detection rate was 89.17 %. OptrA was the most commonly detected ARG. The diversity and abundance of ARGs were significantly higher in poultry and swine manure than in bovine manure. Redundancy analysis presented a strong association between florfenicol and all the three ARGs targeted in the study, and tiamulin showed a significant correlation with optrA. Our results indicated that the residual concentration of florfenicol had a major effect on the...Continue Reading

Citations

Feb 21, 2021·Applied and Environmental Microbiology·Simona FioritiEleonora Giovanetti
May 20, 2021·The Journal of Antimicrobial Chemotherapy·Sonia Nina CoccittoEleonora Giovanetti
Jun 3, 2021·Clinical Microbiology Reviews·Stefan SchwarzYang Wang
Jun 29, 2021·EFSA Journal·UNKNOWN EFSA Panel on Biological Hazards (BIOHAZ)Luisa Peixe
Aug 11, 2021·The Science of the Total Environment·Yitian ShaoYujing Xie

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