Abstract
Our objective was to investigate the association between gene polymorphisms of folate cycle (MTHFR 677 C>T, MTHFR 1298 A>C, MTR 2756 A>G, and MTRR 66 A>G) and the risk of pulmonary embolism (PE) in a case-control study. 177 PE patients (87 women and 90 men) were compared to a healthy control group (461 people, 123 women, 326 men). All of them are residents of Novosibirsk region. SNPs were genotyped by allele-specific PCR. The age distributions of our male and female patients were found to be significantly different. For men, the distribution has two maxima, whereas for women it has only one maximum, which is between the two. This fact stimulated us to perform a sex-specific analysis. No statistically significant difference has been found between distributions of the three genes in our PE patients and healthy controls. However, it was discovered that the TT genotype of MTHFR: 677 C>T polymorphism in men increases the risk of PE in comparison to controls. In fact, the difference increases in the age group over 45years. Also, AA genotype of MTRR 66 A>G polymorphism in women below 45years decreases the risk of PE. The sex-specific multiple linear regression analysis gave us estimates of the relative PE risk associated with MTHFR 67...Continue Reading
References
Apr 1, 1998·Archives of Internal Medicine·M D SilversteinL J Melton
May 3, 2000·American Journal of Epidemiology·L D Botto, Q Yang
Jul 27, 2001·Atherosclerosis·D J GaughanA S Whitehead
Sep 11, 2002·American Journal of Hematology·Marco RuggeriFrancesco Rodeghiero
Feb 7, 2003·The European Respiratory Journal·E Nizankowska-MogilnickaA Szczeklik
Mar 19, 2003·Blood·Leo A J KluijtmansAlexander S Whitehead
Dec 12, 2003·Chest·Clive Kearon
Dec 31, 2003·Thrombosis Research·Veronika M ShmelevaGeoffrey F Savidge
Jan 27, 2005·Journal of Thrombosis and Haemostasis : JTH·M Den HeijerR Clarke
Jan 27, 2005·Journal of Thrombosis and Haemostasis : JTH·J A HeitS S Sommer
Jul 18, 2006·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Iris ScalaGeneroso Andria
Nov 23, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Alexander SemmlerMichael Linnebank
Mar 6, 2008·British Journal of Haematology·Inger Anne NaessJens Hammerstrøm
Oct 27, 2010·Journal of Reconstructive Microsurgery·Dhruv SinghalLifei Guo
Oct 5, 2011·Alimentary Pharmacology & Therapeutics·A OussalahL Peyrin-Biroulet
Dec 26, 2012·Gene·Shengrong OuyangJianxin Wu
Jan 9, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Xiaoming WuWenru Tang
Jan 30, 2013·Fertility and Sterility·Rohini R NairKiran Singh
Mar 9, 2013·PloS One·Boyi YangGuifan Sun
Aug 1, 2013·European Journal of Epidemiology·Benedetto SimoneStefania Boccia
Sep 11, 2013·Indian Journal of Human Genetics·Vandana RaiSushil Kumar Yadav
Citations
May 14, 2017·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Xin LiEnze Jin
May 17, 2018·International Journal of Clinical Practice·Jennifer BillingsJeffrey J Ellis
Jul 3, 2020·Bioscience Reports·Miao GaoXiuping Zuo