Association of follicular fluid volume with membrane stretchability of human metaphase II oocytes following the gonadotropin-releasing hormone agonist protocol during intracytoplasmic sperm injection

Reproductive Medicine and Biology
Taketo InoueYoshiki Yamashita

Abstract

The authors previously revealed the association of the follicular fluid (FF) volume with oolemma stretchability following the gonadotropin-releasing hormone (GnRH) antagonist protocol during intracytoplasmic sperm injection (ICSI). However, the impact of the GnRH agonist protocol on oolemma stretchability remains unclear. Data that were obtained from 74 ICSI cycles were reviewed retrospectively. Controlled ovarian stimulation was performed in accordance with the short GnRH agonist protocol. Each follicle was individually aspirated and assigned to one of six groups, according to the FF volume. The oolemma stretchability during ICSI was evaluated by using a mechanical stimulus for oolemma penetration; that is, oolemma penetration with or without aspiration (high vs low stretchability, respectively). The incidence of low oolemma stretchability was significantly higher in the <1.0 mL group than that in the ≥1.0 mL group. The normal fertilization rate was significantly lower in the <1.0 mL group than that in the 2.0-<3.0 mL group. The rate of blastocyst development was lower in the <1.0 mL group than that in the 3.0-<4.0 mL group. The FF volume potentially was associated with metaphase II oolemma stretchability, fertilization, and b...Continue Reading

References

Oct 2, 1998·Human Reproduction·N H KimK S Chung
May 24, 2006·Microscopy Research and Technique·A Henry SathananthanAlan O Trounson
Jul 11, 2006·Journal of Experimental & Clinical Assisted Reproduction·Kevin S RichterMichael J Tucker
Feb 6, 2008·Fertility and Sterility·Mitchell P RosenMarcelle I Cedars
Nov 9, 2010·Taiwanese Journal of Obstetrics & Gynecology·Tsai-Fang LeeJin-Tsung Su
May 1, 2012·Reproductive Biology and Endocrinology : RB&E·Ana Marcia M CotaJosé G Franco
Sep 19, 2016·Journal of Assisted Reproduction and Genetics·Yamato MizobeYuji Ezono
Oct 14, 2017·Clinical and Experimental Reproductive Medicine·Taketo InoueKazunori Miyazaki

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