Association of FOXP3 Single Nucleotide Polymorphisms With Clinical Outcomes After Allogenic Hematopoietic Stem Cell Transplantation

Annals of Laboratory Medicine
Minjeong NamEun Young Song

Abstract

Forkhead box P3 (FOXP3) is an important marker of regulatory T cells. FOXP3 polymorphisms are associated with autoimmune diseases, cancers, and allograft outcomes. We examined whether single nucleotide polymorphisms (SNPs) at the FOXP3 locus are associated with clinical outcomes after allogenic hematopoietic stem cell transplantation (HSCT). Five FOXP3 SNPs (rs5902434, rs3761549, rs3761548, rs2232365, and rs2280883) were analyzed by PCR-sequencing of 172 DNA samples from allogenic HSCT patients. We examined the relationship between each SNP and the occurrence of graft-versus-host disease (GVHD), post-HSCT infection, relapse, and patient survival. Patients with acute GVHD (grades II-IV) showed higher frequencies of the rs3761549 T/T genotype, rs5902434 ATT/ATT genotype, and rs2232365 G/G genotype than did patients without acute GVHD (P=0.017, odds ratio [OR]=5.3; P=0.031, OR=2.4; and P=0.023, OR=2.6, respectively). Multivariate analysis showed that the TT genotype of rs3761549 was an independent risk factor for occurrence of acute GVHD (P=0.032, hazard ratio=5.6). In contrast, the genotype frequencies of rs3761549 T/T, rs5902434 ATT/ATT, and rs2232365 G/G were lower in patients with post-HSCT infection than in patients without i...Continue Reading

References

Mar 27, 2003·Nature Reviews. Immunology·Matthias G von Herrath, Leonard C Harrison
Feb 10, 2004·European Journal of Immunology·Hans-Willi Mittrücker, Stefan H E Kaufmann
Nov 2, 2004·Nature Reviews. Immunology·Kingston H G Mills
Mar 24, 2005·Nature Immunology·Yasmine Belkaid, Barry T Rouse
Dec 13, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Alexandra H FilipovichMary E D Flowers
Oct 24, 2006·Bone Marrow Transplantation·N T Le, N Chao
Mar 8, 2007·Nature Medicine·Tyler J Curiel
Oct 20, 2007·Nature Reviews. Immunology·Yasmine Belkaid
May 31, 2008·Cell·Shimon SakaguchiMasahiro Ono
Nov 3, 2009·Journal of Dermatological Science·Lin GaoYufeng Liu
Apr 13, 2011·Fertility and Sterility·Gustavo M AndréBianca Bianco
Jun 7, 2011·Bone Marrow Transplantation·A Gratwohl
Feb 22, 2012·Fertility and Sterility·Caio P BarbosaBianca Bianco
Mar 6, 2013·Human Immunology·Anja U EngelaCarla C Baan
May 4, 2013·Journal of Genetics·Julie Massayo Maeda OdaMaria Angelica Ehara Watanabe
Jun 28, 2013·Frontiers in Immunology·Amy J Beres, William R Drobyski
Feb 28, 2014·Frontiers in Immunology·Benjamin D SingerFranco R D'Alessio
Jun 6, 2014·Cancer Investigation·Karim ArnaoutImad A Tabbara
Oct 11, 2014·The Journal of Infectious Diseases·Oriol ManuelUNKNOWN Swiss Transplant Cohort Study
Nov 5, 2014·Oncology Letters·Ling-Ling Jiang, Li-Wei Ruan
Mar 18, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M Fernández-RuizUNKNOWN OPERA Study Group
Oct 20, 2015·Asthma Research and Practice·Cintia Rodrigues MarquesCamila Alexandrina Figueiredo

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Citations

Jun 27, 2019·Cancers·Carmelo GurnariEmiliano Fabiani

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Methods Mentioned

BETA
nucleic acid amplification
PCR

Software Mentioned

SPSS
HaploReg

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