Association of Frailty and Long-Term Survival in Patients Undergoing Coronary Artery Bypass Grafting

Journal of the American Heart Association
Diem T T TranLouise Y Sun

Abstract

Frailty is increasing in prevalence and poses a formidable challenge for clinicians. The cardiac surgery literature consists primarily of small single-center studies with limited follow-up, and the epidemiological features of frailty remain to be elucidated in long-term follow-up. We conducted a population-based, retrospective, cohort study in Ontario, Canada, between 2008 and 2015. Frailty was defined using the Johns Hopkins Adjusted Clinical Groups frailty indicator (a multidimensional instrument validated for research using administrative data). The primary outcome was mortality. Mortality rates were calculated using the Kaplan-Meier method. The hazard of death was assessed using a multivariable Cox proportional hazard model. Of 40 083 patients, 8803 (22%) were frail. At 4±2 years of follow-up, age- and sex-standardized mortality rate per 1000 person-years was higher in frail (33; 95% confidence interval, 29-36) compared with nonfrail (22; 95% confidence interval, 19-24) patients. Frailty was associated with an increased risk of long-term mortality (adjusted hazard ratio, 1.20; 95% confidence interval, 1.12-1.28) and greater differences in the survival of patients between 40 and 74 years of age than in those who were ≥85 yea...Continue Reading

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May 10, 2020·Anesthesia and Analgesia·Christina M Norris, Jacqueline C T Close
Apr 30, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Emma RaymondJuulia Jylhävä
Feb 19, 2019·Journal of the American Heart Association·Angela Lowenstern, Tracy Y Wang
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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

SAS

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