PMID: 15252283Jul 15, 2004Paper

Association of functional opioid receptor genotypes with alcohol dependence in Koreans

Alcoholism, Clinical and Experimental Research
Sung-Gon KimDavid W Oslin

Abstract

The functional polymorphism (A118G) of the mu-opioid receptor gene (OPRM1) is thought to have clinical significance in the treatment of alcohol dependence. This study compared Koreans with one or two copies of the A118G polymorphism seeking treatment for alcohol dependence with a group of non-alcohol-dependent controls. Patients hospitalized for alcohol dependence (n = 112) and a group of non-alcohol-dependent controls (n = 140) were interviewed on aspects of drinking history and psychiatric history. Patients and controls were excluded if they met criteria for any other major psychiatric disorder. Participants were genotyped at the OPRM1 locus. The allele frequency of the Asp40 allele was 0.397 in the alcohol-dependent group, which is consistent with other literature demonstrating this polymorphism to be common in Asian populations. Within the alcohol-dependent subjects, being homozygous for the Asp40 allele was associated with more days drinking than those heterozygous or homozygous for the Asn40 allele. Differences in the allele frequencies between alcohol-dependent and non-alcohol-dependent controls were not significant. These results suggest that having one or two copies of the A118G allele is common among Koreans and may b...Continue Reading

References

Nov 1, 1992·Archives of General Psychiatry·J R VolpicelliC P O'Brien
Nov 1, 1987·Archives of General Psychiatry·M A SchuckitC Risch
Mar 1, 1996·Archives of General Psychiatry·C GianoulakisJ Thavundayil
Oct 1, 1996·Journal of Consulting and Clinical Psychology·A J JaffeS S O'Malley
Dec 17, 1997·Molecular Psychiatry·A W BergenD Goldman
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·C BondL Yu
Jul 10, 1999·Psychoneuroendocrinology·M SmolkaM R Hoehe
Sep 22, 1999·American Journal of Medical Genetics·T TownM Mullan
Aug 10, 2000·The American Journal on Addictions·M A Schuckit
Oct 3, 2001·The American Journal on Addictions·J R MonterossoJ R Volpicelli
Dec 26, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gary S WandAhmed Ali
Mar 11, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Carlos A Hernandez-AvilaHenry R Kranzler
Jun 19, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David W OslinCharles P O'Brien
Sep 10, 2003·Psychiatric Genetics·James J CrowleyDorothy E Grice
Jul 1, 1997·Addiction Biology·W H BerrettiniE Gottheil

❮ Previous
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Citations

May 2, 2012·Human Genetics·Orna LevranMary Jeanne Kreek
Aug 27, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rachel Y ChongGary S Wand
Apr 14, 2006·Current Opinion in Psychiatry·Susumu HiguchiHaruo Kashima
Sep 12, 2006·Addiction Biology·David W OslinCharles P O'Brien
Dec 12, 2012·Pharmacogenomics and Personalized Medicine·Laith N Al-EitanGary K Hulse
Sep 17, 2011·Pharmacogenomics·Shinya Kasai, Kazutaka Ikeda
Nov 6, 2007·Pharmacogenomics·Carmen S van der ZwaluwRutger C M E Engels
Jun 6, 2013·Future Medicinal Chemistry·Christopher R BodleDavid L Roman
Nov 10, 2013·Pharmacology, Biochemistry, and Behavior·Richard C Crist, Wade H Berrettini
Jun 5, 2013·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Noora Rouvinen-LagerströmSirkku T Saarikoski
Jan 16, 2010·Drug and Alcohol Dependence·Stephen D Mague, Julie A Blendy
Mar 24, 2009·Journal of Diabetes and Its Complications·Kuang-I ChengChung-Sheng Lai
Dec 21, 2004·Alcoholism, Clinical and Experimental Research·Lara A Ray, Kent E Hutchison
Sep 20, 2007·Journal of Neurochemistry·Thomas KroslakMary Jeanne Kreek
Feb 15, 2013·Pain Practice : the Official Journal of World Institute of Pain·Mauricio DaherFrancisco A R Neves
Oct 29, 2009·Alcoholism, Clinical and Experimental Research·Robert MirandaPeter M Monti
Feb 8, 2005·Trends in Molecular Medicine·Jörn Lötsch, Gerd Geisslinger
Mar 9, 2005·Peptides·Jadwiga Zalewska-Kaszubska, Elzbieta Czarnecka
Jul 26, 2005·Peptides·Richard J Bodnar, Gad E Klein
Jul 1, 2008·Biological Psychiatry·Ildiko RaczAndreas Zimmer
Feb 16, 2010·Drug and Alcohol Dependence·Eric J VallenderDonna M Platt
May 16, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Xiaoling XueiHoward J Edenberg
Nov 5, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gavin BartMarkus Heilig
Jun 28, 2008·The American Journal of Drug and Alcohol Abuse·Colin N HaileThomas R Kosten
Apr 28, 2006·Yonsei Medical Journal·Young-Chul Jung, Kee Namkoong
Oct 1, 2013·Pharmacological Reviews·Gavril W Pasternak, Ying-Xian Pan
Jul 24, 2018·Journal of Molecular Neuroscience : MN·Madiha AhmedMalik Mumtaz Taqi
Jan 31, 2017·The American Journal on Addictions·Anita CservenkaLara A Ray
Feb 26, 2019·Frontiers in Psychology·Bryn L Y SachdeoNicholas T Bello

❮ Previous
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