Association of functional polymorphisms from brain-derived neurotrophic factor and serotonin-related genes with depressive symptoms after a medical stressor in older adults

PloS One
Kerri S RawsonEric J Lenze

Abstract

Depressive symptoms are common in older adults after a disabling medical event and interfere with rehabilitation and recovery from the disability. This prospective study examined the role of genetic polymorphisms implicated in synaptic integrity and stress-associated depression as predictors of depressive symptoms after hip fracture. We recruited healthy comparisons from the community and participants with hip fracture after surgical fixation from Saint Louis, Missouri hospitals. We examined the valine (Val) to methionine (Met) polymorphism in brain-derived neurotrophic factor (BDNF), serotonin 1A receptor (5HT1a-rs6295) polymorphism, and the serotonin transporter-linked polymorphic region (5HTTLPR) interaction with the rs25531 A to G single nucleotide polymorphism (5HTTLPR-rs25531) as predictors of depressive symptoms. We also examined whether depressive symptoms mediate the influence of BDNF genotype on functional recovery. Among 429 participants with hip fracture, BDNF Met/Met carriers developed significantly more depressive symptoms than Val/Val carriers during a four-week period after the fracture (p=.012). BDNF genotype also predicted functional recovery over the ensuing year, mediated by its effects on depressive symptom...Continue Reading

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Citations

Jan 13, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M SantoroD Quaranta
Dec 22, 2015·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Kaiyuan ChenQingjun Huang
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Jan 3, 2020·International Journal of Geriatric Psychiatry·Emily S BowerEric J Lenze
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Nov 21, 2018·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Hanadi Ajam OughliEric J Lenze

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Methods Mentioned

BETA
genotyping

Software Mentioned

Structure
MEDIATE
SPSS Statistics
SAS
Structure Harvester Web

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