Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study

Arthritis Research & Therapy
Christopher ButtProton Rahman

Abstract

Recent studies have implicated PTPN22 and tp53 in susceptibility to several autoimmune diseases, including rheumatoid arthritis, suggesting that these genes are important in maintaining immune homeostasis. Because autoimmune diseases may share similar susceptibility loci, investigation of these genes in psoriatic arthritis (PsA) is of potential relevance. As a result we investigated known coding polymorphisms in PTPN22 and tp53 in a homogenous Caucasian PsA cohort from Newfoundland, Canada and an admixed Caucasian PsA cohort from Toronto, Canada. We observed a moderate association of the R620W variant of PTPN22 with PsA in the Toronto population only. Because of the conflicting findings reported regarding the association of PTPN22 with PsA, further studies in other PsA populations are warranted.

References

Sep 1, 1995·The Journal of Clinical Investigation·G S FiresteinN J Zvaifler
Jun 29, 1999·Acta Dermato-venereologica·A Hannuksela-SvahnK Vähäkangas
Nov 25, 2000·Clinical and Experimental Immunology·H TaubertD Riemann
May 15, 2004·Arthritis Research & Therapy·Nancy J OlsenThomas M Aune
Jul 27, 2004·American Journal of Human Genetics·Chieko KyogokuTimothy W Behrens
Jan 14, 2005·Annals of the Rheumatic Diseases·G SalvadorJ D Cañete
Feb 15, 2005·Annals of the Rheumatic Diseases·P Rahman, J T Elder
Aug 16, 2005·The Journal of Investigative Dermatology·Ioana NistorJames T Elder
Aug 16, 2011·Journal of Assisted Reproduction and Genetics·Wenru TangYing Luo

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Citations

Mar 6, 2010·Seminars in Immunopathology·Stephanie M StanfordNunzio Bottini
Feb 3, 2009·Nature Clinical Practice. Rheumatology·Kristine E NogralesAnne M Bowcock
Mar 18, 2011·Arthritis Research & Therapy·Kristina JunebladGerd-Marie Alenius
Jul 9, 2014·Nature Reviews. Rheumatology·Stephanie M Stanford, Nunzio Bottini
Jan 20, 2010·Current Opinion in Rheumatology·Madhura Castelino, Anne Barton
Mar 18, 2008·The British Journal of Dermatology·Rh Ll SmithJ Worthington
May 1, 2012·Molecular Biology Reports·Yu-Fu Chen, Jeffrey S Chang
Jan 20, 2018·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Ghaleb Bin HuraibAbdulrahaman Al-Asmari

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Methods Mentioned

BETA
chips
genotyping
PCR

Software Mentioned

MassARRAY
Sequenom SpectroTYPER - RT

Related Concepts

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